Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Name:Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:139080-52-7
Molecular Formula:C₄₀H₃₄N₅O₇S₃*K
Molecular Weight:832.036
Hs Code.:

Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 5 articles about Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 139080-45-8
(6R,7R)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 139080-52-7
Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With potassium 2-ethylhexanoate; methoxybenzene; trifluoroacetic acid; at 0 - 5 ℃; for 2h;

Reference yield:

: 76609-91-1
2-(2-tritylamino-4-thiazolyl)-2-methoxyiminoacetyl chloride

: 139080-52-7
Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃, Et₃N / acetone / 1.5 h

2: 62 percent / CH₂Cl₂; methanol / 2 h / Ambient temperature

3: 68 percent / 1.) trifluoroacetic acid, anisole, 2.) potassium 2-ethyl hexanoate / 2 h / 0 - 5 °C

With sodium hydrogencarbonate; potassium 2-ethylhexanoate; methoxybenzene; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; acetone;

Reference yield:

: (6R,7R)-7-Amino-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 139080-52-7
Potassium; (6R,7R)-7-{2-[(Z)-methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(toluene-4-sulfonylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃, Et₃N / acetone / 1.5 h

2: 62 percent / CH₂Cl₂; methanol / 2 h / Ambient temperature

3: 68 percent / 1.) trifluoroacetic acid, anisole, 2.) potassium 2-ethyl hexanoate / 2 h / 0 - 5 °C

With sodium hydrogencarbonate; potassium 2-ethylhexanoate; methoxybenzene; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; acetone;