7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester
• CAS No.: 1027866-52-9
• Molecular Formula: C₃₂H₂₇F₃N₂O₆
• Molecular Weight: 592.571

Synonyms:

Chemical Property of 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

There total 1 articles about 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-bromo-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester + 2-Benzyloxycarbonyl-5-tributylstannylisoindoline (178445-32-4) → 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1027866-52-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In xylene; for 2h; Heating;

Reference yield:

7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (1027866-52-9) → 7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1026079-13-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 50 ℃; for 1h;

upstream raw materials:

2-Benzyloxycarbonyl-5-tributylstannylisoindoline

Downstream raw materials:

7-(2-benzyloxycarbonyl-2,3-dihydro-1H-isoindol-5-yl)-1-cyclopropyl-8-difluoromethoxy-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

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