GNE-781

Base Information

• Chemical Name: GNE-781
• CAS No.: 1936422-33-1
• Molecular Formula: C₂₇H₃₃F₂N₇O₂
• Molecular Weight: 525.602

Synonyms:

Chemical Property of GNE-781

Chemical Property:

• Melting Point: 135-140oC
• Boiling Point: 800.7±65.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

GNE-781 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: GNE-781 is a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein, binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.

Technology Process of GNE-781

There total 14 articles about GNE-781 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1-(1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]-pyridin-3-yl)-1,2,3,4-tetrahydroquinoline + imidazole-1-carboxylic acid N-methylamide (72002-25-6) → GNE-781 (1936422-33-1)

Guidance literature:

With triethylamine; In dichloromethane; at 25 ℃; for 36h;

DOI:10.1021/acs.jmedchem.7b00796

Reference yield:

7-methylquinoline (612-60-2) → GNE-781 (1936422-33-1)

Guidance literature:

Multi-step reaction with 8 steps

1: selenium(IV) oxide / 8.08 h / 160 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 16.33 h / 0 - 20 °C

3: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 24.33 h / 0 - 90 °C

4: N-Bromosuccinimide / dichloromethane / 16.33 h / 0 - 20 °C

5: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

6: sodium t-butanolate; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; ruphos / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere

7: trifluoroacetic acid / dichloromethane / 3 h / 30 °C

8: triethylamine / dichloromethane / 36 h / 25 °C

With selenium(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; diethylamino-sulfur trifluoride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; methanol; dichloromethane; water; 5: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.7b00796

Reference yield:

quinoline-7-carbaldehyde (49573-30-0) → GNE-781 (1936422-33-1)

Guidance literature:

Multi-step reaction with 7 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 16.33 h / 0 - 20 °C

2: boron trifluoride diethyl etherate; sodium cyanoborohydride / methanol / 24.33 h / 0 - 90 °C

3: N-Bromosuccinimide / dichloromethane / 16.33 h / 0 - 20 °C

4: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 18 h / 110 °C / Inert atmosphere

5: sodium t-butanolate; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; ruphos / 1,4-dioxane / 16 h / 120 °C / Inert atmosphere

6: trifluoroacetic acid / dichloromethane / 3 h / 30 °C

7: triethylamine / dichloromethane / 36 h / 25 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; diethylamino-sulfur trifluoride; chloro-(2-dicyclohexylphosphino-2’,6’-diisopropoxy-1,1‘-biphenyl)[2-(2-aminoethyl)phenyl] palladium(ll) methyl-tert-butyl ether adduct; boron trifluoride diethyl etherate; sodium cyanoborohydride; potassium carbonate; triethylamine; trifluoroacetic acid; sodium t-butanolate; ruphos; In 1,4-dioxane; methanol; dichloromethane; water; 4: |Suzuki Coupling;

DOI:10.1021/acs.jmedchem.7b00796

upstream raw materials:

7-methylquinoline

imidazole-1-carboxylic acid N-methylamide

quinoline-7-carbaldehyde

ethyl 3-((tert-butoxycarbonyl)(2-cyanoethyl)amino)propanoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1936422-33-1 GNE-781

Send

Send

Metric Ton KG G Pound L ML

Send

Send