GPhos

Base Information

Chemical Name:GPhos
CAS No.:2489243-29-8
Molecular Formula:C₃₅H₅₃O₂P
Molecular Weight:536.778
Hs Code.:

Synonyms:

Suppliers and Price of GPhos

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of GPhos

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of GPhos

There total 5 articles about GPhos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 3-(tert-butoxy)-2-iodo-2',6'-diisopropyl-6-methoxy-1,1'-biphenyl

: 16523-54-9
chlorodicyclohexylphosphane

: 2489243-29-8
GPhos

Guidance literature:: 3-(tert-butoxy)-2-iodo-2',6'-diisopropyl-6-methoxy-1,1'-biphenyl; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Sealed tube; Inert atmosphere; Schlenk technique;

chlorodicyclohexylphosphane; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 3h; Inert atmosphere; Sealed tube; Schlenk technique;
DOI:10.1021/jacs.0c06139

Reference yield:

: 82830-49-7
2-fluoro-1,4-dimethoxybenzene

: 2489243-29-8
GPhos

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C / Inert atmosphere; Sealed tube

1.2: 0.17 h / -78 °C / Inert atmosphere; Sealed tube

2.1: magnesium; ethylene dibromide / tetrahydrofuran / 70 °C / Schlenk technique; Inert atmosphere; Sealed tube

2.2: 70 °C / Inert atmosphere; Sealed tube

2.3: 20 °C / Inert atmosphere; Sealed tube

3.1: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Sealed tube

4.1: trifluorormethanesulfonic acid / dichloromethane / -78 °C / Inert atmosphere; Sealed tube

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Sealed tube; Inert atmosphere; Schlenk technique

5.2: 3 h / -78 - 20 °C / Inert atmosphere; Sealed tube; Schlenk technique

With n-butyllithium; trifluorormethanesulfonic acid; tert.-butyl lithium; boron tribromide; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; cyclohexane; pentane;
DOI:10.1021/jacs.0c06139

Reference yield:

: 2-fluoro-3-iodo-1,4-dimethoxybenzene

: 2489243-29-8
GPhos

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 70 °C / Schlenk technique; Inert atmosphere; Sealed tube

1.2: 70 °C / Inert atmosphere; Sealed tube

1.3: 20 °C / Inert atmosphere; Sealed tube

2.1: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere; Sealed tube

3.1: trifluorormethanesulfonic acid / dichloromethane / -78 °C / Inert atmosphere; Sealed tube

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 1 h / -78 °C / Sealed tube; Inert atmosphere; Schlenk technique

4.2: 3 h / -78 - 20 °C / Inert atmosphere; Sealed tube; Schlenk technique

With trifluorormethanesulfonic acid; tert.-butyl lithium; boron tribromide; magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/jacs.0c06139