C₁₄H₁₆F₃NO₃

Base Information

• Chemical Name: C₁₄H₁₆F₃NO₃
• CAS No.: 1312927-91-5
• Molecular Formula: C₁₄H₁₆F₃NO₃
• Molecular Weight: 303.281
• Mol file: 1312927-91-5.mol

Synonyms:

Chemical Property of C₁₄H₁₆F₃NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₆F₃NO₃

There total 1 articles about C₁₄H₁₆F₃NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Trifluoroacetyl)-γ-aminobutyric acid (50632-83-2) → C14H16F3NO3 (1312927-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / dichloromethane; N,N-dimethyl-formamide / 35 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 0.75 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;

DOI:10.1021/jm1016126

Reference yield:

C14H16F3NO3 (1312927-91-5) → C58H84N6O11

Guidance literature:

Multi-step reaction with 8 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

3: hydrogenchloride / methanol / 65 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

5: pyridine; palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol

6: sodium hydrogencarbonate / dichloromethane; water / 5 h

7: lithium hydroxide / tetrahydrofuran; water

8: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / Inert atmosphere

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm1016126

Reference yield:

C14H16F3NO3 (1312927-91-5) → C27H35N3O7 (1312927-93-7)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

3: hydrogenchloride / methanol / 65 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm1016126

upstream raw materials:

N-(Trifluoroacetyl)-γ-aminobutyric acid

Downstream raw materials:

C₂₇H₃₅N₃O₇

C₁₉H₂₉N₃O₅

C₃₅H₅₉N₃O₆

C₃₄H₅₇N₃O₆