2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

Base Information

Chemical Name:2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime
CAS No.:719303-10-3
Molecular Formula:C₃₈H₄₆FN₅O₁₀Si
Molecular Weight:779.895
Hs Code.:

2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde <i>O</i>-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

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Chemical Property of 2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

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Technology Process of 2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

There total 8 articles about 2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₉H₆₄FN₅O₁₂Si

: 719303-10-3
2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

Guidance literature:: With trichloroacetic acid; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1081/NCN-120028337

Reference yield:

: 171176-06-0
5'-O-phthalimido-2'-fluorothymidine

: 719303-10-3
2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / imidazole / dimethylformamide / 12 h / 20 °C

2: 95 percent / methylhydrazine / CH₂Cl₂ / 1 h / 0 °C

3: acetic acid / CH₂Cl₂; toluene / 35 °C / atmospheric pressure

4: 0.54 g / Cl₃CCO₂H / CH₂Cl₂ / 0.17 h / 20 °C

With 1H-imidazole; acetic acid; methylhydrazine; trichloroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1081/NCN-120028337

Reference yield:

: 719302-84-8
5'-O-amino-3'-O-tert-butyldiphenylsilyl-2'-fluorothymidine

: 719303-10-3
2-hydroxymethyl-4-methoxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-carbaldehyde O-[3-(tert-butyl-diphenyl-silanyloxy)-4-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-oxime

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / CH₂Cl₂; toluene / 35 °C / atmospheric pressure

2: 0.54 g / Cl₃CCO₂H / CH₂Cl₂ / 0.17 h / 20 °C

With acetic acid; trichloroacetic acid; In dichloromethane; toluene;
DOI:10.1081/NCN-120028337