N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

Base Information

Chemical Name:N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide
CAS No.:110613-55-3
Molecular Formula:C₃₁H₄₈N₄O₇
Molecular Weight:588.745
Hs Code.:

N-<N-<(tert-butyloxy)carbonyl>-L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

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Chemical Property of N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

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Technology Process of N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

There total 7 articles about N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 110613-39-3
N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene

: 110613-55-3,110660-47-4
N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm00394a008

Reference yield:

: 3887-02-3
N-methyl methacrylamide

: 110613-55-3,110660-47-4
N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-butyllithium, 2.) ClTi(O-iPr)3

2: HCl(g) / dioxane / 1 h / Ambient temperature

3: 1.) 4-methylmorpholine / 1.) CH₂Cl₂, DMF, 2.) CH₂Cl₂, DMF, from -15 deg C to RT, 2.5 h

4: 97 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

With 4-methyl-morpholine; triisopropoxytitanium(IV) chloride; hydrogenchloride; n-butyllithium; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00394a008

Reference yield:

: 55677-48-0
N-tert-butyloxycarbonyl-L-phenylalanyl-L-alanine

: 110613-55-3,110660-47-4
N--L-phenylalanyl-L-alanyl>-5(S)-amino-6-cyclohexyl-4(S)-hydroxy-2-(N-isopentylcarbamoyl)hex-1-ene 1,2-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methylmorpholine / CH₂Cl₂; dimethylformamide / 0.08 h / -15 °C

2: 1.) 4-methylmorpholine / 1.) CH₂Cl₂, DMF, 2.) CH₂Cl₂, DMF, from -15 deg C to RT, 2.5 h

3: 97 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 18 h / Ambient temperature

With 4-methyl-morpholine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a008