(3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

Base Information

Chemical Name:(3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one
CAS No.:6089-71-0
Molecular Formula:C₁₅H₂₄O₃
Molecular Weight:252.354
Hs Code.:

Synonyms:

Suppliers and Price of (3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of (3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

There total 1 articles about (3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 481-07-2
β-santonin

: 6089-71-0,18045-58-4,22387-66-2,29395-96-8,32981-64-9,65017-96-1,67895-88-9,67895-89-0,98796-78-2,127617-02-1,132185-32-1,132185-33-2
(11R)-3α,6α-dihydroxy-eudesman-12-oic acid-6-lactone

: 32638-47-4
(11R)-6α-hydroxy-3-oxo-5β-eudesman-12-oic acid-lactone

Guidance literature:: With potassium hydroxide; anschliessend Hydrieren an Platin und Erhitzen der eingeengten Reaktionsloesung mit wss. Salzsaeure;
DOI:10.1016/0040-4020(58)80007-1

Reference yield:

: 6089-71-0,18045-58-4,22387-66-2,29395-96-8,32981-64-9,65017-96-1,67895-88-9,67895-89-0,98796-78-2,127617-02-1,132185-32-1,132185-33-2
(3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

: 132185-41-2,1351-48-0,17237-80-8,34319-09-0
6β-vulgarin

Guidance literature:: Multi-step reaction with 8 steps

1: 58 percent / 2,2'-bipyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

2: 61 percent / Br₂ / CCl₄; CHCl₃ / 0.17 h / Ambient temperature

3: 94 percent / Li₂CO₃, LiBr / dimethylformamide / 1.25 h / 120 °C

4: 57 percent / 30percent H₂O₂, Na₂CO₃ / H₂O; tetrahydrofuran / 2 h / 35 - 40 °C

5: 28 percent / 100percent hydrazine hydrate / tetrahydrofuran / 0.08 h / Heating

6: 98 percent / Jones reagent / acetone / 0 °C

7: 7.5 percent / ethanol / 144 h / Rhizopus nigricans cultures

8: 1) Zn, acetic acid, 2) MCPBA / 1) reflux, 20 min, 2) H₂CCl₂, rt, 48 h

With jones reagent; dihydrogen peroxide; bromine; lithium carbonate; sodium carbonate; hydrazine hydrate; acetic acid; 3-chloro-benzenecarboperoxoic acid; 2,2'-bipyridinium chlorochromate; lithium bromide; zinc; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)87881-9

Reference yield:

: 6089-71-0,18045-58-4,22387-66-2,29395-96-8,32981-64-9,65017-96-1,67895-88-9,67895-89-0,98796-78-2,127617-02-1,132185-32-1,132185-33-2
(3S,3aS,5aS,9S,9aS,9bR)-8-Hydroxy-3,5a,9-trimethyl-decahydro-naphtho[1,2-b]furan-2-one

: 132185-40-1,1351-48-0,17237-80-8,34319-09-0
4-epi-6β-vulgarin

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / 2,2'-bipyridinium chlorochromate / CH₂Cl₂ / 12 h / Ambient temperature

2: 61 percent / Br₂ / CCl₄; CHCl₃ / 0.17 h / Ambient temperature

3: 94 percent / Li₂CO₃, LiBr / dimethylformamide / 1.25 h / 120 °C

4: 57 percent / 30percent H₂O₂, Na₂CO₃ / H₂O; tetrahydrofuran / 2 h / 35 - 40 °C

5: 28 percent / 100percent hydrazine hydrate / tetrahydrofuran / 0.08 h / Heating

6: 98 percent / Jones reagent / acetone / 0 °C

7: 7.5 percent / ethanol / 144 h / Rhizopus nigricans cultures

With jones reagent; dihydrogen peroxide; bromine; lithium carbonate; sodium carbonate; hydrazine hydrate; 2,2'-bipyridinium chlorochromate; lithium bromide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)87881-9