(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

Base Information

Chemical Name:(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester
CAS No.:79329-04-7
Molecular Formula:C₃₁H₃₃ClN₂O₇S
Molecular Weight:613.131
Hs Code.:

(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

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Chemical Property of (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

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Technology Process of (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

There total 3 articles about (1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 865-47-4
potassium tert-butylate

: 79328-89-5
(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 6-ethyl ester 2-(2,2,2-trichloro-ethyl) ester

: 79329-04-7
(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

: 79328-93-1
(1R,4R,6R)-6-(1H-Indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-tert-butyl ester 6-methyl ester

Guidance literature:: In tetrahydrofuran; for 0.0833333h; Ambient temperature;
DOI:10.1021/jo00337a003

Reference yield:

: 66531-21-3
1-<(2,2,2-trichloroethoxy)carbonyl>-1,2-dihydropyridine

: 79329-04-7
(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / 48 h / 105 °C

2: 26 percent / tetrahydrofuran / 0.08 h / Ambient temperature

In tetrahydrofuran;
DOI:10.1021/jo00337a003

Reference yield:

: 71295-00-6
Ethyl 2-(1-benzenesulfonylindol-2-yl)-acrylate

: 79329-04-7
(1S,4S,6S)-6-(1-Benzenesulfonyl-1H-indol-2-yl)-2-aza-bicyclo[2.2.2]oct-7-ene-2,6-dicarboxylic acid 2-((Z)-2-tert-butoxy-2-chloro-vinyl) ester 6-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 31 percent / 48 h / 105 °C

2: 26 percent / tetrahydrofuran / 0.08 h / Ambient temperature

In tetrahydrofuran;
DOI:10.1021/jo00337a003