Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Base Information

• Chemical Name: Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester
• CAS No.: 221565-01-1
• Molecular Formula: C₂₆H₃₂N₆O₁₀
• Molecular Weight: 588.574
• Mol file: 221565-01-1.mol

Synonyms:

Chemical Property of Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

There total 2 articles about Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid 1-acetoxymethyl-3-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester (221565-00-0) → Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester (221565-01-1)

Guidance literature:

With pyridine; hydrogen fluoride; for 4h; Ambient temperature;

DOI:10.1021/jm980605u

Reference yield:

4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol (221564-99-4) → Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester (221565-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 16 h / Ambient temperature

2: HF, pyridine / 4 h / Ambient temperature

With pyridine; hydrogen fluoride;

DOI:10.1021/jm980605u

Reference yield:

Acetic acid 1-acetoxymethyl-3-{9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester (221565-01-1) → Acetic acid 1-acetoxymethyl-3-{9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphoryloxy]-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 1 h / Ambient temperature

2: NEt₃ / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; triethylamine; In dichloromethane;

DOI:10.1021/jm980605u

upstream raw materials:

acetic acid 1-acetoxymethyl-3-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester

4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-butane-1,2-diol

Downstream raw materials:

Acetic acid 1-acetoxymethyl-3-{9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-propyl ester