7-Hydroxy-3',4',6-trimethoxyisoflavone

Base Information

• Chemical Name: 7-Hydroxy-3',4',6-trimethoxyisoflavone
• CAS No.: 24126-90-7
• Molecular Formula: C18H16 O6
• Molecular Weight: 328.321
• Mol file: 24126-90-7.mol

Synonyms:Isoflavone,7-hydroxy-3',4',6-trimethoxy- (8CI); Cladrastin

Chemical Property of 7-Hydroxy-3',4',6-trimethoxyisoflavone

Chemical Property:

• PSA: 78.13000
• LogP: 3.19140

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Hydroxy-3',4',6-trimethoxyisoflavone

There total 5 articles about 7-Hydroxy-3',4',6-trimethoxyisoflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-(2,4-dihydroxy-5-methoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone (24126-91-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 7-hydroxy-3-(3,4-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one (24126-90-7)

Guidance literature:

1-(2,4-dihydroxy-5-methoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone; N,N-dimethyl-formamide; With boron trifluoride diethyl etherate; trichlorophosphate; at 70 - 75 ℃; for 1h;

With water; at 90 - 95 ℃; for 0.5h;

DOI:10.1007/s10600-018-2440-x

Reference yield:

4-methoxybenzene-1,3-diol (6100-60-3) → 7-hydroxy-3-(3,4-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one (24126-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate

1.2: Reflux

2.1: boron trifluoride diethyl etherate; trichlorophosphate / 1 h / 70 - 75 °C

2.2: 0.5 h / 90 - 95 °C

With boron trifluoride diethyl etherate; trichlorophosphate;

DOI:10.1007/s10600-018-2440-x

Reference yield:

dimethyl sulfate (77-78-1) + 7-(β-D-glucopyranosyloxy)-6-methoxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one → 7-hydroxy-3-(3,4-dimethoxyphenyl)-6-methoxy-4H-chromen-4-one (24126-90-7)

Guidance literature:

dimethyl sulfate; 7-(β-D-glucopyranosyloxy)-6-methoxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; With potassium carbonate; In acetone; for 6h; Heating;

With hydrogenchloride; In ethanol; water; for 3h; Heating;

DOI:10.1007/BF02236288

upstream raw materials:

dimethyl sulfate

4-methoxybenzene-1,3-diol

3,4-dimethoxyphenylacetonitrile

1-(2,4-dihydroxy-5-methoxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone

Refernces

• 1、 Butayarov,Batirov,Tadzhibaev,Yuldashev. "Flavonoids of Caragana alaica". . p. 628 - 630. Retrieved 2007/10/03.