(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

Chemical Name:(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
CAS No.:1026427-32-6
Molecular Formula:C₂₉H₃₀BrClFNO₅
Molecular Weight:606.916
Hs Code.:

(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Chemical Property of (R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

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Technology Process of (R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 6 articles about (R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 703-59-3
homophthalic anhydride

: 1026427-32-6
(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / triethylamine / 1.) THF, RT, 1 h, 2.) DMF, reflux, 15 h

2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

3: 2.4 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

4: 94 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / Ambient temperature

5: SOCl₂ / 2 h / Heating

With thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017

Reference yield:

: (4-bromo-2-fluorophenyl)methanamine mono HCl salt

: 1026427-32-6
(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 51 percent / triethylamine / 1.) THF, RT, 1 h, 2.) DMF, reflux, 15 h

2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

3: 2.4 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

4: 94 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / Ambient temperature

5: SOCl₂ / 2 h / Heating

With thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017

Reference yield:

: 129688-66-0
2-<(4-bromo-2-fluorophenyl)methyl>-1,3,(2H,4H)-isoquinolinedione

: 1026427-32-6
(R)-2-(4-Bromo-2-fluoro-benzyl)-4-chlorocarbonylmethyl-1,3-dioxo-1,2,3,4-tetrahydro-isoquinoline-4-carboxylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

2: 2.4 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

3: 94 percent / CF₃CO₂H / CH₂Cl₂ / 5 h / Ambient temperature

4: SOCl₂ / 2 h / Heating

With thionyl chloride; potassium carbonate; trifluoroacetic acid; lithium hexamethyldisilazane; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017