1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

Base Information

Chemical Name:1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃
CAS No.:1439382-05-4
Molecular Formula:C₃₂H₅₀N₂O₃
Molecular Weight:510.761
Hs Code.:

1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D<sub>3</sub>

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Chemical Property of 1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

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Technology Process of 1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

There total 17 articles about 1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1439381-99-3
C₅₀H₉₂N₂O₃Si₃

: 1439382-05-4
1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ml400098w

Reference yield:

: methyl 4,6-O-benzylidene-3-deoxy-3-C-ethenyl-α-D-altropyranoside

: 1439382-05-4
1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

Guidance literature:: Multi-step reaction with 16 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydroxide; dihydrogen peroxide / 16 h / 20 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5.1: barium carbonate; N-Bromosuccinimide / tetrachloromethane / 2 h / 0 °C / Reflux

6.1: sodium cyanoborohydride; zinc / propan-1-ol; water / 0.67 h / 20 °C / Reflux

7.1: pyridine / 15.5 h / 0 - 20 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

9.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

9.2: 2 h / -78 - 20 °C / Inert atmosphere

10.1: potassium carbonate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere

11.1: 2,6-dimethylpyridine / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere

12.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 °C / Inert atmosphere

12.2: 1 h / -78 - 20 °C

13.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

14.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

14.2: 59 h / 0 °C / Inert atmosphere; Reflux

15.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 110 °C / Inert atmosphere

16.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With pyridine; 2,6-dimethylpyridine; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; triethylamine; barium carbonate; sodium hydroxide; zinc; In tetrahydrofuran; methanol; propan-1-ol; tetrachloromethane; hexane; dichloromethane; water; toluene; mineral oil;
DOI:10.1021/ml400098w

Reference yield:

: 1439381-92-6
(3R,4S,5R)-3,5-bis(tert-butyldimethylsilyloxy)-4-[2-(mesyloxy)-ethyl]oct-1-en-7-yne

: 1439382-05-4
1α,25-dihydroxy-2α-[2-(imidazole-1-yl)ethyl]vitamin D₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 59 h / 0 °C / Inert atmosphere; Reflux

2.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 110 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran; toluene; mineral oil;
DOI:10.1021/ml400098w