(22S)-vitamin D₃

Base Information

Chemical Name:(22S)-vitamin D₃
CAS No.:80320-78-1
Molecular Formula:C₂₈H₄₆O₃
Molecular Weight:430.671
Hs Code.:

Synonyms:

Suppliers and Price of (22S)-vitamin D₃

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (22S)-vitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (22S)-vitamin D₃

There total 21 articles about (22S)-vitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132101-64-5,27943-46-0
3-methyl-3-(tetrahydro-2H-pyran-2-yloxy)butyne

: 80320-78-1,80320-79-2
(22R)-25-hydroxy-22-methoxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: n-butyllithium / hexane; tetrahydrofuran / 0 deg C, 10 min, -78 deg C, 30 min

2: H₂ / platinum black / methanol / 0.67 h / Ambient temperature

3: sodium hydride / tetrahydrofuran / 1 h / Heating

4: HCl / methanol; tetrahydrofuran / 1 h / Ambient temperature

5: pyridine / Ambient temperature

6: 1.) N-bromosuccinimide, 2.) p-toluenesulfonic acid / 1.) CCl₄, reflux, 2.) acetone, RT

7: benzene; ethanol / Heating; Irradiation

8: 5percent KOH / methanol; tetrahydrofuran

With pyridine; hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; hydrogen; sodium hydride; toluene-4-sulfonic acid; platinum; In tetrahydrofuran; methanol; ethanol; hexane; benzene;
DOI:10.1248/cpb.29.2254

Reference yield:

: 22145-61-5
3β-(tetrahydropyran-2-yloxy)-23,24-dinorchol-5-en-22-al

: 80320-78-1,80320-79-2
(22R)-25-hydroxy-22-methoxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: n-butyllithium / hexane; tetrahydrofuran / 0 deg C, 10 min, -78 deg C, 30 min

2: H₂ / platinum black / methanol / 0.67 h / Ambient temperature

3: sodium hydride / tetrahydrofuran / 1 h / Heating

4: HCl / methanol; tetrahydrofuran / 1 h / Ambient temperature

5: pyridine / Ambient temperature

6: 1.) N-bromosuccinimide, 2.) p-toluenesulfonic acid / 1.) CCl₄, reflux, 2.) acetone, RT

7: benzene; ethanol / Heating; Irradiation

8: 5percent KOH / methanol; tetrahydrofuran

With pyridine; hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; hydrogen; sodium hydride; toluene-4-sulfonic acid; platinum; In tetrahydrofuran; methanol; ethanol; hexane; benzene;
DOI:10.1248/cpb.29.2254

Reference yield:

: 132101-64-5,27943-46-0
3-methyl-3-(tetrahydro-2H-pyran-2-yloxy)butyne

: 80320-78-1,80320-79-2
(22S)-vitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: n-butyllithium / hexane; tetrahydrofuran / 0 deg C, 10 min, -78 deg C, 30 min

2: H₂ / platinum black / methanol / 0.67 h / Ambient temperature

3: sodium hydride / tetrahydrofuran / 1 h / Heating

4: HCl / methanol; tetrahydrofuran / 1 h / Ambient temperature

5: pyridine / Ambient temperature

6: 1.) N-bromosuccinimide, 2.) p-toluenesulfonic acid / 1.) CCl₄, reflux, 2.) acetone, RT

7: benzene; ethanol / Heating; Irradiation

8: 5percent KOH / methanol; tetrahydrofuran

With pyridine; hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; n-butyllithium; hydrogen; sodium hydride; toluene-4-sulfonic acid; platinum; In tetrahydrofuran; methanol; ethanol; hexane; benzene;
DOI:10.1248/cpb.29.2254