1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

Base Information

Chemical Name:1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide
CAS No.:1033708-02-9
Molecular Formula:C₃₁H₃₆Cl₂N₄O₃S
Molecular Weight:615.624
Hs Code.:

1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

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Chemical Property of 1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

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Technology Process of 1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

There total 9 articles about 1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033707-10-6
(4S,5R)-4,5-bis(4-chlorophenyl)-4-methylimidazolidine-2-thione

: 1033708-02-9
1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / Reflux

2: sodium hydroxide / water; ethanol / 60 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: trifluoroacetic acid / chloroform

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091

Reference yield:

: 1033707-12-8
Ethyl (5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate

: 1033708-02-9
1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water; ethanol / 60 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: trifluoroacetic acid / chloroform

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091

Reference yield:

: 1033707-13-9
(5R,6S)-5,6-bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylic acid

: 1033708-02-9
1-{[(5R,6S)-5,6-Bis(4-chlorophenyl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-2-yl]carbonyl}-N-(2-methoxyethyl)-N-methyl-L-prolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

2: trifluoroacetic acid / chloroform

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.091