Technology Process of 3-[5-chloro-4-(2,4-difluorobenzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-[(R)-2-(2-methoxyethyl)-3-oxo-isoxazolidin-4-yl]-4-methylbenzamide
There total 8 articles about 3-[5-chloro-4-(2,4-difluorobenzyloxy)-6-oxo-6H-pyrimidin-1-yl]-N-[(R)-2-(2-methoxyethyl)-3-oxo-isoxazolidin-4-yl]-4-methylbenzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: methanol / 0 °C / Reflux
2.1: 4-methyl-morpholine / dichloromethane / -5 - 20 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
4.1: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 20 °C
5.1: N-chloro-succinimide; dichloro-acetic acid / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere
6.1: formic acid; dihydrogen peroxide / 20 °C
6.2: 4 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
7.2: 20 °C
With
4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; formic acid; water; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 4-methyl-morpholine / dichloromethane / -5 - 20 °C / Inert atmosphere
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C
3.1: sodium hydroxide; water / 1,4-dioxane / 1.5 h / 20 °C
4.1: N-chloro-succinimide; dichloro-acetic acid / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere
5.1: formic acid; dihydrogen peroxide / 20 °C
5.2: 4 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
6.2: 20 °C
With
4-methyl-morpholine; dichloro-acetic acid; N-chloro-succinimide; formic acid; water; dihydrogen peroxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide;
In
1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-chloro-succinimide; dichloro-acetic acid / 1,2-dichloro-ethane / 3 h / 65 °C / Inert atmosphere
2.1: formic acid; dihydrogen peroxide / 20 °C
2.2: 4 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C
3.2: 20 °C
With
dichloro-acetic acid; N-chloro-succinimide; formic acid; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; HATU;
In
1,2-dichloro-ethane; N,N-dimethyl-formamide;