(1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Base Information

• Chemical Name: (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide
• CAS No.: 1097133-53-3
• Molecular Formula: C₂₂H₂₀Cl₂N₆O₃
• Molecular Weight: 487.345
• Mol file: 1097133-53-3.mol

Synonyms:

Chemical Property of (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide

There total 5 articles about (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,3S,5S)-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-yl-benzylamide (1097263-88-1) + C11H14Cl2O2Si → (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide (1097133-53-3)

Guidance literature:

(1S,3S,5S)-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-yl-benzylamide; C₁₁H₁₄Cl₂O₂Si; With pyridine; In dichloromethane; at 20 ℃;

With methanol;

DOI:10.1039/c5md00479a

Reference yield:

(1S,3S,5S)-3-(5-chloro-2-tetrazol-1-yl-benzylcarbamoyl)-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (1097134-20-7) → (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide (1097133-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / methanol / 20 °C

2: pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; water; In methanol; dichloromethane;

DOI:10.1039/c5md00479a

Reference yield:

(R)-3-chloromandelic acid (16273-37-3,32222-43-8,52950-16-0,61008-98-8) → (1S,3S,5S)-2-[(R)-2-(3-chlorophenyl)-2-hydroxyacetyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-ylbenzylamide (1097133-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; pyridine / 20 °C

1.2: 0 - 20 °C

2.1: pyridine / dichloromethane / 20 °C

With pyridine; dmap; In dichloromethane;

DOI:10.1039/c5md00479a

upstream raw materials:

(1S,3S,5S)-3-(5-chloro-2-tetrazol-1-yl-benzylcarbamoyl)-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester

(1S,3S,5S)-2-aza-bicyclo[3.1.0]hexane-3-carboxylic acid 5-chloro-2-tetrazol-1-yl-benzylamide

(R)-3-chloromandelic acid

(1S,3S,5S)-2-(tert-butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid