methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate

Base Information

• Chemical Name: methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate
• CAS No.: 1370731-45-5
• Molecular Formula: C₁₇H₁₂ClNO₂S
• Molecular Weight: 329.807
• Mol file: 1370731-45-5.mol

Synonyms:

Chemical Property of methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate

There total 6 articles about methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 2-(2-chlorophenyl)thiazole-4-carboxylate (1311864-08-0) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate (1370731-45-5)

Guidance literature:

With silver(I) acetate; palladium diacetate; Trimethylacetic acid; at 120 ℃; for 12h;

DOI:10.1039/c2cc00081d

Reference yield:

2-chloro-benzaldehyde (89-98-5) → methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate (1370731-45-5)

Guidance literature:

Multi-step reaction with 6 steps

1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / Reflux

2: acetic anhydride / Reflux

3: sodium hydrogencarbonate / ethanol; water

4: potassium hydrogencarbonate / N,N-dimethyl-formamide / 0 - 20 °C

5: copper diacetate / N,N-dimethyl-formamide / 120 °C

6: silver(I) acetate; palladium diacetate; Trimethylacetic acid / 12 h / 120 °C

With hydroxylamine hydrochloride; silver(I) acetate; copper diacetate; palladium diacetate; acetic anhydride; sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; Trimethylacetic acid; In methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1039/c2cc00081d

Reference yield:

C11H10ClNO2S → methyl 2-(o-chlorophenyl)-5-phenylthiazole-4-carboxylate (1370731-45-5)

Guidance literature:

Multi-step reaction with 2 steps

1: copper diacetate / N,N-dimethyl-formamide / 120 °C

2: silver(I) acetate; palladium diacetate; Trimethylacetic acid / 12 h / 120 °C

With silver(I) acetate; copper diacetate; palladium diacetate; Trimethylacetic acid; In N,N-dimethyl-formamide;

DOI:10.1039/c2cc00081d

upstream raw materials:

methyl 2-(2-chlorophenyl)thiazole-4-carboxylate

benzene

2-Chlorobenzonitrile

2-chloro benzaldehyde oxime