(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:1308377-91-4
Molecular Formula:C₂₉H₃₀F₄N₆O₃
Molecular Weight:586.589
Hs Code.:

(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

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Chemical Property of (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

There total 5 articles about (R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₈F₄N₆O₅

: 1308377-91-4
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308375-93-0
{(R)-2-[3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-piperazin-1-yl-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

: 1308377-91-4
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

1.2: 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 830346-49-1
{(R)-2-[5-bromo-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester

: 1308377-91-4
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-5-(4-(isoxazol-3-ylmethyl)piperazin-1-yl)-6-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 2 h / 120 °C / Microwave irradiation

2.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C / 760.05 Torr

3.1: 1,2-dichloro-ethane / 0.33 h / 20 °C

3.2: 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071