C₇H₈BrFN₂O

Base Information

Chemical Name:C₇H₈BrFN₂O
CAS No.:1379365-84-0
Molecular Formula:C₇H₈BrFN₂O
Molecular Weight:235.056
Hs Code.:

C<sub>7</sub>H<sub>8</sub>BrFN<sub>2</sub>O

Synonyms:

Suppliers and Price of C₇H₈BrFN₂O

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Chemical Property of C₇H₈BrFN₂O

Chemical Property:

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Technology Process of C₇H₈BrFN₂O

There total 1 articles about C₇H₈BrFN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 239122-51-1
5-bromo-3-fluoro-2-methoxyaniline

: 1379365-84-0
C₇H₈BrFN₂O

Guidance literature:: 5-bromo-3-fluoro-2-methoxyaniline; With hydrogenchloride; sodium nitrite; In water; at -10 ℃; Inert atmosphere;

With tin(ll) chloride; In water;
DOI:10.1021/jm5006226

Reference yield:

: 1379365-84-0
C₇H₈BrFN₂O

: 1617505-24-4
C₃₁H₂₆F₅N₃O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

1.3: 0.17 h / 0 °C / Inert atmosphere

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Sealed tube

3.1: zinc; ammonium chloride / methanol; ethyl acetate / 20 °C / Inert atmosphere

4.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 100 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In methanol; Dimethyl ether; dichloromethane; ethyl acetate; toluene; 1.1: |Fischer Indole Synthesis / 5.1: |Suzuki Coupling;
DOI:10.1021/jm5006226

Reference yield:

: 1379365-84-0
C₇H₈BrFN₂O

: 1617505-25-5
C₃₁H₂₆ClF₄N₃O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere

1.3: 0.17 h / 0 °C / Inert atmosphere

2.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / Inert atmosphere; Sealed tube

3.1: zinc; ammonium chloride / methanol; ethyl acetate / 20 °C / Inert atmosphere

4.1: dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 100 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In methanol; Dimethyl ether; dichloromethane; ethyl acetate; toluene; 1.1: |Fischer Indole Synthesis / 5.1: |Suzuki Coupling;
DOI:10.1021/jm5006226