Technology Process of 13-(tert-butyldiphenylsilyloxy)tridec-8(Z)-enoic acid
There total 8 articles about 13-(tert-butyldiphenylsilyloxy)tridec-8(Z)-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 0 - 20 °C
2.1: n-butyllithium / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran; hexanes / 3.5 h / -78 - 0 °C / Inert atmosphere
2.2: 15 h / -78 - 20 °C
3.1: methanol / pyridinium p-toluenesulfonate / 10 h / 0 °C
4.1: hydrogen; sodium tetrahydroborate / ethylenediamine; nickel(II) acetate tetrahydrate / ethanol
5.1: Jones reagent / water; acetone / 3 h / -40 - -10 °C
With
methanol; sodium tetrahydroborate; Jones reagent; n-butyllithium; hydrogen;
nickel(II) acetate tetrahydrate; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; ethylenediamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexanes; ethanol; dichloromethane; water; acetone;
5.1: Jones Oxidation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran; hexanes / 3.5 h / -78 - 0 °C / Inert atmosphere
2.2: 15 h / -78 - 20 °C
3.1: methanol / pyridinium p-toluenesulfonate / 10 h / 0 °C
4.1: hydrogen; sodium tetrahydroborate / ethylenediamine; nickel(II) acetate tetrahydrate / ethanol
5.1: Jones reagent / water; acetone / 3 h / -40 - -10 °C
With
1H-imidazole; methanol; sodium tetrahydroborate; Jones reagent; n-butyllithium; hydrogen;
nickel(II) acetate tetrahydrate; pyridinium p-toluenesulfonate; ethylenediamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexanes; ethanol; dichloromethane; water; acetone;
5.1: Jones Oxidation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran; hexanes / 3.5 h / -78 - 0 °C / Inert atmosphere
1.2: 15 h / -78 - 20 °C
2.1: methanol / pyridinium p-toluenesulfonate / 10 h / 0 °C
3.1: hydrogen; sodium tetrahydroborate / ethylenediamine; nickel(II) acetate tetrahydrate / ethanol
4.1: Jones reagent / water; acetone / 3 h / -40 - -10 °C
With
methanol; sodium tetrahydroborate; Jones reagent; n-butyllithium; hydrogen;
nickel(II) acetate tetrahydrate; pyridinium p-toluenesulfonate; ethylenediamine;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexanes; ethanol; water; acetone;
4.1: Jones Oxidation;