methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate

Base Information

• Chemical Name: methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate
• CAS No.: 91534-13-3
• Molecular Formula: C₁₂H₂₀O₃
• Molecular Weight: 212.289
• Mol file: 91534-13-3.mol

Synonyms:

Chemical Property of methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate

There total 5 articles about methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-((1R,2S)-2-Formyl-1-methyl-cyclohexyl)-propionic acid (150934-10-4) → methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate (91534-13-3,109263-20-9)

Guidance literature:

In diethyl ether;

Reference yield:

4a-methyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one (826-56-2) → methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate (91534-13-3,109263-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Li, liq. NH₃, 2) NEt₃ / 1) THF, 15 min, 2) THF

2: 1) O₃, Sudan Red III / 1) CH₂Cl₂, MeOH

With ammonia; lithium; ozone; triethylamine; 1-[{4-(phenylazo)-phenyl}-azo]-2-naphthalenol;

DOI:10.1039/c39840000253

Reference yield:

trans-1,2,3,4,4a,5,6,8a-octahydro-4a-methyl-7-trimethylsiloxynaphthalene (53912-10-0,109263-19-6,115305-95-8) → methyl trans-3-(2'-formyl-1'-methylcyclohexyl)propionate (91534-13-3,109263-20-9)

Guidance literature:

Multi-step reaction with 2 steps

1: O₃ / CH₂Cl₂; methanol / -78 °C

2: 64 percent / diethyl ether

With ozone; In methanol; diethyl ether; dichloromethane;

upstream raw materials:

diazomethane

3-((1R,2S)-2-Formyl-1-methyl-cyclohexyl)-propionic acid

trans-1,2,3,4,4a,5,6,8a-octahydro-4a-methyl-7-trimethylsiloxynaphthalene

trans-10-methyldecal-2-one

Downstream raw materials:

3-{(1R,2S)-2-[1-(tert-Butyl-dimethyl-silanyloxy)-allyl]-1-methyl-cyclohexyl}-propionaldehyde

trans-2-methyl-2-(3'-methylenepent-4'-enyl)cyclohexyl vinyl ketone

methyl trans-3-<2'-<1''-(3''',5'''-dinitrobenzoyloxy)prop-2''-enyl>-1'-methylcyclohexyl>propionate

trans-5-<2'-<1''-(dimethyl-t-butylsiloxy)prop-2''-enyl>-1'-methylcyclohexyl>-3-trimethylsilylmethylpent-1-en-3-ol