methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate

Base Information

Chemical Name:methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate
CAS No.:91108-33-7
Molecular Formula:C₁₀H₁₇NO₃
Molecular Weight:199.25
Hs Code.:

Synonyms:1H-Pyrrolizine-1-carboxylicacid, hexahydro-2-hydroxy-2-methyl-, methyl ester, (1a,2b,7aa)- (9CI); 1H-Pyrrolizine-1-carboxylic acid, hexahydro-2-hydroxy-2-methyl-,methyl ester, (1a,2b,7aa)-(?à)-; (?à)-Isotussilagine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate

Chemical Property:

Vapor Pressure:0.000502mmHg at 25°C
Boiling Point:279°C at 760 mmHg
Flash Point:122.5°C
Density:1.2g/cm³

Purity/Quality:

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Technology Process of methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate

There total 5 articles about methyl (1S,2S,7aS)-2-hydroxy-2-methylhexahydro-1H-pyrrolizine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90965-34-7,90989-32-5
3-(Methylsulfonyloxymethyl)-3-methyl-4-methoxycarbonyl-2-oxa-1-azabicyclo<3.3.0>octan

: 80151-77-5,91108-31-5,91108-32-6,91108-33-7,147730-89-0,147730-90-3
1-Methoxycarbonyl-2-hydroxy-2-methyl-pyrrolizidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 24h;
DOI:10.1002/ardp.19843170504

Reference yield:

: 924-50-5
Methyl 3,3-dimethylacrylate

: 80151-77-5,91108-31-5,91108-32-6,91108-33-7,147730-89-0,147730-90-3
1-Methoxycarbonyl-2-hydroxy-2-methyl-pyrrolizidine

Guidance literature:: Multi-step reaction with 5 steps

1: 64.4 percent / NBS, azo-bis-isobutyronitrile / CCl₄ / 2 h / Heating

2: 35.8 percent / Ag₂O / H₂O / 48 h / Ambient temperature

3: 32.2 percent / CHCl₃ / 1.) room temp., 4 h, 2.) reflux, 12 h

4: 86.2 percent / pyridine / 3 h / 0 °C

5: H₂ / 10percent Pd/C / methanol / 24 h

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; silver(l) oxide; palladium on activated charcoal; In methanol; tetrachloromethane; chloroform; water;
DOI:10.1002/ardp.19843170504

Reference yield:

: 19041-17-9,27652-13-7,50465-52-6
methyl 4-bromo-3-methylbut-2-enoate

: 80151-77-5,91108-31-5,91108-32-6,91108-33-7,147730-89-0,147730-90-3
1-Methoxycarbonyl-2-hydroxy-2-methyl-pyrrolizidine

Guidance literature:: Multi-step reaction with 4 steps

1: 35.8 percent / Ag₂O / H₂O / 48 h / Ambient temperature

2: 32.2 percent / CHCl₃ / 1.) room temp., 4 h, 2.) reflux, 12 h

3: 86.2 percent / pyridine / 3 h / 0 °C

4: H₂ / 10percent Pd/C / methanol / 24 h

With pyridine; hydrogen; silver(l) oxide; palladium on activated charcoal; In methanol; chloroform; water;
DOI:10.1002/ardp.19843170504