Technology Process of (2S,3S,4S)-2,3,4-tribenzyloxy-5-((benzyloxy)methyl)-5-hexenal
There total 6 articles about (2S,3S,4S)-2,3,4-tribenzyloxy-5-((benzyloxy)methyl)-5-hexenal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -78 ℃;
for 0.666667h;
DOI:10.1039/b704509c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 74 percent / pyridine / 72 h / 20 °C
2.1: 86 percent / acetic anhydride; DMSO / 16 h / 20 °C
3.1: nBuLi / tetrahydrofuran / 1 h / -78 °C
3.2: 79 percent / tetrahydrofuran / 16 h / 0 - 20 °C
4.1: 61 percent / aq. HCl / acetic acid / 0.67 h / 20 °C
5.1: oxalyl chloride; triethylamine; DMSO / CH2Cl2 / 0.67 h / -78 °C
With
pyridine; n-butyllithium; oxalyl dichloride; acetic anhydride; dimethyl sulfoxide; triethylamine;
hydrogenchloride;
In
tetrahydrofuran; dichloromethane; acetic acid;
2.1: Swern oxidation / 3.2: Wittig reaction / 5.1: Swern oxidation;
DOI:10.1039/b704509c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: nBuLi / tetrahydrofuran / 1 h / -78 °C
1.2: 79 percent / tetrahydrofuran / 16 h / 0 - 20 °C
2.1: 61 percent / aq. HCl / acetic acid / 0.67 h / 20 °C
3.1: oxalyl chloride; triethylamine; DMSO / CH2Cl2 / 0.67 h / -78 °C
With
n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
hydrogenchloride;
In
tetrahydrofuran; dichloromethane; acetic acid;
1.2: Wittig reaction / 3.1: Swern oxidation;
DOI:10.1039/b704509c
