Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

Base Information

Chemical Name:Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester
CAS No.:141762-93-8
Molecular Formula:C₃₈H₄₆O₉Si
Molecular Weight:674.863
Hs Code.:

Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

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Suppliers and Price of Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

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Chemical Property of Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

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Technology Process of Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

There total 11 articles about Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 141762-92-7
C₄₁H₅₂O₁₀Si

: 141762-93-8
Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

Guidance literature:: With boron tribromide; In dichloromethane; 1) -78 deg C, 1 h, 2) -43 deg C, 1.5 h;
DOI:10.1016/S0040-4039(00)74149-9

Reference yield:

: 130575-40-5,149400-23-7
(2S,3S,3aR,5R,6aS,7aR,8S,10R,11R,11aR,11bS,11cR)-11c-(tert-Butyl-diphenyl-silanyloxymethyl)-10-hydroxy-5,11-dimethoxy-2-methoxymethoxy-3,8,11a-trimethyl-tetradecahydro-6-oxa-benzo[de]anthracen-1-one

: 141762-93-8
Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

Guidance literature:: Multi-step reaction with 11 steps

1: Dess-Martin periodinane reagent / CH₂Cl₂ / 1 h

2: 10percent HCl / tetrahydrofuran / 24 h

3: POCl₃, pyridine / 1 h / 80 °C

4: 1) OsO₄, 2) NaHSO₃ / 1) pyridine, 0 deg C, 1 h, 2) 2 h

5: 75 percent / Dess-Martin periodinane reagent / CH₂Cl₂ / 1.5 h

6: 82 percent / NEt₃, DMAP / CH₂Cl₂

7: 1) LiHMDS, TMSCl, 2) NBS / 1) THF, -78 deg C to rt

8: 93 percent / Li₂CO₃, LiBr / dimethylformamide / 0.75 h / 120 °C

9: 10percent HCl / tetrahydrofuran / 0.5 h

10: DMAP, pyridine / CH₂Cl₂

11: 46 percent / BBr₃ / CH₂Cl₂ / 1) -78 deg C, 1 h, 2) -43 deg C, 1.5 h

With pyridine; hydrogenchloride; dmap; N-Bromosuccinimide; osmium(VIII) oxide; chloro-trimethyl-silane; boron tribromide; lithium carbonate; Dess-Martin periodane; sodium hydrogensulfite; triethylamine; lithium bromide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74149-9

Reference yield:

: 141762-94-9,149400-47-5,149400-48-6
(2S,3S,3aR,5R,6aS,7aR,8S,11R,11aR,11bS,11cR)-11c-(tert-Butyl-diphenyl-silanyloxymethyl)-5-hydroxy-11-methoxy-2-methoxymethoxy-3,8,11a-trimethyl-dodecahydro-6-oxa-benzo[de]anthracene-1,10-dione

: 141762-93-8
Acetic acid (2S,3S,3aR,4S,6aS,7aR,11R,11aR,11bS,11cR)-11c-(tert-butyl-diphenyl-silanyloxymethyl)-2,11-dihydroxy-3,8,11a-trimethyl-1,5,10-trioxo-1,2,3,3a,4,5,6a,7,7a,10,11,11a,11b,11c-tetradecahydro-6-oxa-benzo[de]anthracen-4-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: POCl₃, pyridine / 1 h / 80 °C

2: 1) OsO₄, 2) NaHSO₃ / 1) pyridine, 0 deg C, 1 h, 2) 2 h

3: 75 percent / Dess-Martin periodinane reagent / CH₂Cl₂ / 1.5 h

4: 82 percent / NEt₃, DMAP / CH₂Cl₂

5: 1) LiHMDS, TMSCl, 2) NBS / 1) THF, -78 deg C to rt

6: 93 percent / Li₂CO₃, LiBr / dimethylformamide / 0.75 h / 120 °C

7: 10percent HCl / tetrahydrofuran / 0.5 h

8: DMAP, pyridine / CH₂Cl₂

9: 46 percent / BBr₃ / CH₂Cl₂ / 1) -78 deg C, 1 h, 2) -43 deg C, 1.5 h

With pyridine; hydrogenchloride; dmap; N-Bromosuccinimide; osmium(VIII) oxide; chloro-trimethyl-silane; boron tribromide; lithium carbonate; Dess-Martin periodane; sodium hydrogensulfite; triethylamine; lithium bromide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74149-9