9-Hydroxy-N-desmethylclobazam

Base Information

Chemical Name:9-Hydroxy-N-desmethylclobazam
CAS No.:70643-29-7
Molecular Formula:C₁₅H₁₁ClN₂O₃
Molecular Weight:302.717
Hs Code.:
UNII:382CCF6CWU

Synonyms:9-Hydroxy-N-desmethylclobazam;Clobazam metabolite M10;382CCF6CWU;UNII-382CCF6CWU;70643-29-7;8-Chloro-6-hydroxy-1-phenyl-5H-1,5-benzodiazepine-2,4-dione;8-Chloro-6-hydroxy-1-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione;1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 8-chloro-6-hydroxy-1-phenyl-

Suppliers and Price of 9-Hydroxy-N-desmethylclobazam

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Chemical Property of 9-Hydroxy-N-desmethylclobazam

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:302.0458199
Heavy Atom Count:21
Complexity:425

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C(=O)NC2=C(C=C(C=C2O)Cl)N(C1=O)C3=CC=CC=C3

Technology Process of 9-Hydroxy-N-desmethylclobazam

There total 5 articles about 9-Hydroxy-N-desmethylclobazam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62-53-3
aniline

: 70643-29-7
8-Chlor-1,5-dihydro-6-hydroxy-1-phenyl-2H-1,5-benzodiazepin-2,4(3H)-dion

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaAc / 0.67 h / 140 °C / Heating

2: 1.) pyridine, 2.) sat. NaHCO₃ / 1.) toluene, reflux, 2 h, 2.) room temp., 2 h

3: 1.) H₂, 2.) conc. HCl / 1.) Pd/C / 1.) ethanol, 2.) room temp., 1 d

With pyridine; hydrogenchloride; hydrogen; sodium acetate; sodium hydrogencarbonate; palladium on activated charcoal;

Reference yield:

: 74672-01-8
3,5-dichloro-2-nitroanisole

: 70643-29-7
8-Chlor-1,5-dihydro-6-hydroxy-1-phenyl-2H-1,5-benzodiazepin-2,4(3H)-dion

Guidance literature:: Multi-step reaction with 3 steps

1: 6.5 percent / NaAc / 3 h / Heating

2: 1.) pyridine, 2.) sat. NaHCO₃ / 1.) toluene, reflux, 2 h, 2.) room temp., 2 h

3: 1.) H₂, 2.) conc. HCl / 1.) Pd/C / 1.) ethanol, 2.) room temp., 1 d

With pyridine; hydrogenchloride; hydrogen; sodium acetate; sodium hydrogencarbonate; palladium on activated charcoal;

Reference yield:

: 74672-02-9
3,5-dichloro-2-nitrophenol

: 70643-29-7
8-Chlor-1,5-dihydro-6-hydroxy-1-phenyl-2H-1,5-benzodiazepin-2,4(3H)-dion

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / NaAc / 0.67 h / 140 °C / Heating

2: 1.) pyridine, 2.) sat. NaHCO₃ / 1.) toluene, reflux, 2 h, 2.) room temp., 2 h

3: 1.) H₂, 2.) conc. HCl / 1.) Pd/C / 1.) ethanol, 2.) room temp., 1 d

With pyridine; hydrogenchloride; hydrogen; sodium acetate; sodium hydrogencarbonate; palladium on activated charcoal;