10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

Base Information

• Chemical Name: 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one
• CAS No.: 1357458-28-6
• Molecular Formula: C₁₈H₁₄Cl₂N₂O
• Molecular Weight: 345.228
• Mol file: 1357458-28-6.mol

Synonyms:

Chemical Property of 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one

There total 3 articles about 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-allyl-N-phenyl-1H-indole-2-carboxamide (545339-34-2) → 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one (1357458-28-6)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); potassium carbonate; copper dichloride; In acetonitrile; for 3h; Reflux;

DOI:10.1002/adsc.201100614

Reference yield:

N-allyl-N-phenylamine (589-09-3) → 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one (1357458-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 0 - 20 °C

2: dichloro bis(acetonitrile) palladium(II); potassium carbonate; copper dichloride / acetonitrile / 3 h / Reflux

With dmap; dichloro bis(acetonitrile) palladium(II); potassium carbonate; dicyclohexyl-carbodiimide; copper dichloride; In dichloromethane; acetonitrile;

DOI:10.1002/adsc.201100614

Reference yield:

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → 10-chloro-4-(chloromethyl)-2-phenyl-3,4-dihydropyrazino[1,2-a]indol-1(2H)-one (1357458-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 48 h / 0 - 20 °C

2: dichloro bis(acetonitrile) palladium(II); potassium carbonate; copper dichloride / acetonitrile / 3 h / Reflux

With dmap; dichloro bis(acetonitrile) palladium(II); potassium carbonate; dicyclohexyl-carbodiimide; copper dichloride; In dichloromethane; acetonitrile;

DOI:10.1002/adsc.201100614

upstream raw materials:

N-allyl-N-phenylamine

Indole-2-carboxylic acid

N-allyl-N-phenyl-1H-indole-2-carboxamide