6,7-dibenzyloxy-1-ethoxyisochroman

Base Information

• Chemical Name: 6,7-dibenzyloxy-1-ethoxyisochroman
• CAS No.: 161200-70-0
• Molecular Formula: C₂₅H₂₆O₄
• Molecular Weight: 390.479
• Mol file: 161200-70-0.mol

Synonyms:

Chemical Property of 6,7-dibenzyloxy-1-ethoxyisochroman

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dibenzyloxy-1-ethoxyisochroman

There total 1 articles about 6,7-dibenzyloxy-1-ethoxyisochroman which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

2-<3,4-bis(benzyloxy)phenyl>ethanol (96826-11-8) + orthoformic acid triethyl ester (122-51-0) → 6,7-dibenzyloxy-1-ethoxyisochroman (161200-70-0)

Guidance literature:

With boron trifluoride diethyl etherate; for 4h; Ambient temperature;

DOI:10.1248/cpb.39.1126

Reference yield: 72.0%

6,7-dibenzyloxy-1-ethoxyisochroman (161200-70-0) → 2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde (161200-71-1)

Guidance literature:

With acetyl chloride; 1) reflux, 2.5 h, 2) 90-100 deg C, 1 h;

DOI:10.1248/cpb.39.1126

Reference yield:

6,7-dibenzyloxy-1-ethoxyisochroman (161200-70-0) → 6,7-Bis-benzyloxy-2-((S)-2-hydroxy-1-phenyl-ethyl)-3,4-dihydro-isoquinolinium; chloride

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / acetyl chloride / 1) reflux, 2.5 h, 2) 90-100 deg C, 1 h

2: AcOH / ethanol / 10 h / Ambient temperature

With acetic acid; acetyl chloride; In ethanol;

DOI:10.1248/cpb.39.1126

upstream raw materials:

2-<3,4-bis(benzyloxy)phenyl>ethanol

orthoformic acid triethyl ester

Downstream raw materials:

2-(2-chloroethyl)-4,5-dimethoxybenzaldehyde