methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Base Information

Chemical Name:methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate
CAS No.:1367468-12-9
Molecular Formula:C₁₀H₁₁NO₂
Molecular Weight:177.203
Hs Code.:

Synonyms:

Suppliers and Price of methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

There total 9 articles about methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367468-08-3
2-allyl 1-methyl (R)-1,3-dihydro-2H-isoindole-1,2-dicarboxylate

: 781597-60-2,111605-85-7
methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate

: 1367468-12-9,111605-85-7
methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Guidance literature:: With 1,3-dimethylbarbituric acid; palladium diacetate; triphenylphosphine; In dichloromethane; at 35 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300250h

Reference yield:

: 1367468-10-7
(R)-2-benzyl 1-methyl 1,3-dihydro-2H-isoindole-1,2-dicarboxylate

: 781597-60-2,111605-85-7
methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate

: 1367468-12-9,111605-85-7
methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 0.25h;
DOI:10.1021/ol300250h

Reference yield:

: 1367467-96-6
tert-butyl (+/-)-1-hydroxy-1,3-dihydro-2H-isoindole-2-carboxylate

: 781597-60-2,111605-85-7
methyl (S)-1,3-dihydro-2H-isoindole-1-carboxylate

: 1367468-12-9,111605-85-7
methyl (R)-1,3-dihydro-2H-isoindole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium p-toluenesulfonate / 2 h / 20 °C

2.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.1: water; sodium hydroxide / 3 h / 60 °C

3.2: 20 °C

4.1: hydrogenchloride; water; acetic acid / 72 h / Reflux

5.1: thionyl chloride / 24 h / 20 °C / Cooling with ice

6.1: Pseudomonas cepacia lipase / toluene / 48 h / 60 °C / Inert atmosphere; Enzymatic reaction

7.1: palladium 10% on activated carbon; hydrogen / methanol / 0.25 h / 20 °C

With hydrogenchloride; thionyl chloride; Pseudomonas cepacia lipase; palladium 10% on activated carbon; boron trifluoride diethyl etherate; water; hydrogen; pyridinium p-toluenesulfonate; acetic acid; sodium hydroxide; In methanol; dichloromethane; toluene;
DOI:10.1021/ol300250h