C₂₂H₂₀F₂N₄O

Base Information

• Chemical Name: C₂₂H₂₀F₂N₄O
• CAS No.: 1426689-14-6
• Molecular Formula: C₂₂H₂₀F₂N₄O
• Molecular Weight: 394.424
• Mol file: 1426689-14-6.mol

Synonyms:

Chemical Property of C₂₂H₂₀F₂N₄O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀F₂N₄O

There total 4 articles about C₂₂H₂₀F₂N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate (205383-87-5) → C22H20F2N4O (1426689-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C

3: 0 - 20 °C / Acidic conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; water; acetonitrile; 2: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.01.017

Reference yield:

1-bromo-4-(bromomethyl)-2,5-difluorobenzene (486460-10-0) → C22H20F2N4O (1426689-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C

3: 0 - 20 °C / Acidic conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; In tetrahydrofuran; water; acetonitrile; 2: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.01.017

Reference yield:

C23H23BrF2N2O3 (1426689-28-2) → C22H20F2N4O (1426689-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 160 °C

2: 0 - 20 °C / Acidic conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In tetrahydrofuran; water; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2013.01.017

upstream raw materials:

tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate

1-bromo-4-(bromomethyl)-2,5-difluorobenzene

C₂₃H₂₃BrF₂N₂O₃

C₂₇H₂₈F₂N₄O₃