t-butyl 7β-acetamido>-7α-formamido-cephalosporanate

Base Information

• Chemical Name: t-butyl 7β-acetamido>-7α-formamido-cephalosporanate
• CAS No.: 86062-49-9
• Molecular Formula: C₃₄H₄₀N₆O₁₄S
• Molecular Weight: 788.789
• Mol file: 86062-49-9.mol

Synonyms:

Chemical Property of t-butyl 7β-acetamido>-7α-formamido-cephalosporanate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl 7β-acetamido>-7α-formamido-cephalosporanate

There total 5 articles about t-butyl 7β-acetamido>-7α-formamido-cephalosporanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

t-butyl 7β-amino-7α-formamidocephalosporanate (86062-30-8) + (D)-2-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-(3,4-diacetoxyphenyl)acetic acid (86061-90-7) → t-butyl 7β-acetamido>-7α-formamido-cephalosporanate (86062-49-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 72h; Ambient temperature;

Reference yield:

t-butyl 7β-amino-7α-(methylthio)cephalosporanate (54820-94-9) → t-butyl 7β-acetamido>-7α-formamido-cephalosporanate (86062-49-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / pyridine / CH₂Cl₂ / 0 °C

2: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature

3: 75 percent / pyridine / CH₂Cl₂

4: 45 percent / potassium dihydrogen phosphate, zinc / 6 h

5: 35 percent / DCC / CH₂Cl₂ / 72 h / Ambient temperature

With pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; dicyclohexyl-carbodiimide; zinc; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

t-butyl 7α-(methylthio)-7β-<(2,2,2-trichloroethoxy)carbonylamino>cephalosporanate (86062-28-4) → t-butyl 7β-acetamido>-7α-formamido-cephalosporanate (86062-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / mercury(II) acetate, ammonia / dimethylformamide / -40 degC then allowed to warm to room temperature

2: 75 percent / pyridine / CH₂Cl₂

3: 45 percent / potassium dihydrogen phosphate, zinc / 6 h

4: 35 percent / DCC / CH₂Cl₂ / 72 h / Ambient temperature

With pyridine; potassium dihydrogenphosphate; mercury(II) diacetate; ammonia; dicyclohexyl-carbodiimide; zinc; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

t-butyl 7β-amino-7α-formamidocephalosporanate

(D)-2-(4-ethyl-2,3-dioxopiperazin-1-ylcarbonylamino)-2-(3,4-diacetoxyphenyl)acetic acid

t-butyl 7β-amino-7α-(methylthio)cephalosporanate

t-butyl 7α-amino-7β-<(2,2,2-trichloroethoxy)carbonylamino>cephalosporanate