Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Base Information

Chemical Name:Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate
CAS No.:126556-78-3
Molecular Formula:C₂₄H₂₇FN₅O₇S*Na
Molecular Weight:571.562
Hs Code.:

Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

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Chemical Property of Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

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Technology Process of Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

There total 4 articles about Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126556-80-7
(2S,5R,6S)-6-{(R)-2-[(4-Ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 126556-78-3
Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)76199-5

Reference yield:

: 126556-83-0
(2S,5R,6S)-6-Amino-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzyl ester

: 126556-78-3
Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) bistrimethylsilylacetamide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, pyridine

2: H₂ / Pd/C (10percent) / tetrahydrofuran

With N,O-bis-(trimethylsilyl)-acetamide; hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)76199-5

Reference yield:

: 40353-21-7
(5R)-6c-fluoromethyl-3,3-dimethyl-6t-(4-nitro-benzylideneamino)-7-oxo-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid benzyl ester

: 126556-78-3
Sodium; (2S,5R,6S)-6-{(R)-2-[(4-ethyl-2,3-dioxo-piperazine-1-carbonyl)-amino]-2-phenyl-acetylamino}-6-fluoromethyl-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 19 percent / TsOH, Girard's T_. / CH₂Cl₂ / 3 h / 0 °C

2: 1.) bistrimethylsilylacetamide / 1.) CH₂Cl₂; 2.) CH₂Cl₂, pyridine

3: H₂ / Pd/C (10percent) / tetrahydrofuran

With N,O-bis-(trimethylsilyl)-acetamide; hydrogen; girard's reagent T; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)76199-5