Technology Process of pyrayafoline D
There total 10 articles about pyrayafoline D which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -5 ℃;
for 0.166667h;
Inert atmosphere;
DOI:10.1039/c4ob00367e
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper diacetate; Trimethylacetic acid; palladium diacetate / 3 h / 110 °C / Microwave irradiation; Inert atmosphere
2.1: boron tribromide / dichloromethane / 14.8 h / -78 - 20 °C / Inert atmosphere
3.1: copper dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 30.5 h / 20 °C / Inert atmosphere
3.2: 23 h / Reflux; Inert atmosphere
4.1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / -5 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; copper diacetate; palladium diacetate; boron tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; Trimethylacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c4ob00367e
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1H-imidazole / N,N-dimethyl-formamide / 21.5 h / 20 °C / Inert atmosphere
2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate; palladium diacetate / toluene / 28 h / 100 °C / Inert atmosphere
3.1: copper diacetate; Trimethylacetic acid; palladium diacetate / 3 h / 110 °C / Microwave irradiation; Inert atmosphere
4.1: boron tribromide / dichloromethane / 14.8 h / -78 - 20 °C / Inert atmosphere
5.1: copper dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 30.5 h / 20 °C / Inert atmosphere
5.2: 23 h / Reflux; Inert atmosphere
6.1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide; tetrahydrofuran / 0.17 h / -5 °C / Inert atmosphere
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1H-imidazole; tetrabutyl ammonium fluoride; copper diacetate; palladium diacetate; boron tribromide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; copper dichloride; Trimethylacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
2.1: |Buchwald-Hartwig Coupling;
DOI:10.1039/c4ob00367e
