L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate

Base Information

• Chemical Name: L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate
• CAS No.: 75816-44-3
• Molecular Formula: C₆H₃N₃O₇*C₂₂H₃₉N₅O₇S
• Molecular Weight: 746.753
• Mol file: 75816-44-3.mol

Synonyms:

Chemical Property of L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate

There total 10 articles about L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Ser-Leu-OBut (28252-48-4) → L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate (75816-44-3)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) hydrogen, 2.) 0.4N-hydrogen chloride / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) methanol, -15 deg C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 70 percent / triethylamine / dimethylformamide / 12 h / Ambient temperature

5: 96 percent / 1N hydrogen chloride in methanol / 0.5 h / Ambient temperature

6: 70 percent / 95percent trifluoroacetic acid / 0.67 h / Ambient temperature

7: 35 percent / dicyclohexylcarbodi-imide, N-hydroxysuccinimide / dimethylformamide / 96 h / 4 °C

8: 1.) hydrogen bromide gas / 1.) trifluoroacetic acid, phosphorous acid diethyl ester, -5 deg C, 1 h, room temperature, 2 h, 2.) reflux

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

N-Cbz-L-Isoleucine (3160-59-6) → L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate (75816-44-3)

Guidance literature:

Multi-step reaction with 8 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

3: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

4: 70 percent / triethylamine / dimethylformamide / 12 h / Ambient temperature

5: 96 percent / 1N hydrogen chloride in methanol / 0.5 h / Ambient temperature

6: 70 percent / 95percent trifluoroacetic acid / 0.67 h / Ambient temperature

7: 35 percent / dicyclohexylcarbodi-imide, N-hydroxysuccinimide / dimethylformamide / 96 h / 4 °C

8: 1.) hydrogen bromide gas / 1.) trifluoroacetic acid, phosphorous acid diethyl ester, -5 deg C, 1 h, room temperature, 2 h, 2.) reflux

With 4-methyl-morpholine; hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

Z-Ile-O-COOiBu (41446-04-2) → L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester picrate (75816-44-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 90 percent / triethylamine / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temperature, 1 h

2: 1.) hydrogen, 2.) 0.4N-hydrogene chloride in methanol / 1.) 10percent palladium-charcoal / 1.) 1percent acetic acid in methanol, 2.5 h, 2.) -15 deg C

3: 70 percent / triethylamine / dimethylformamide / 12 h / Ambient temperature

4: 96 percent / 1N hydrogen chloride in methanol / 0.5 h / Ambient temperature

5: 70 percent / 95percent trifluoroacetic acid / 0.67 h / Ambient temperature

6: 35 percent / dicyclohexylcarbodi-imide, N-hydroxysuccinimide / dimethylformamide / 96 h / 4 °C

7: 1.) hydrogen bromide gas / 1.) trifluoroacetic acid, phosphorous acid diethyl ester, -5 deg C, 1 h, room temperature, 2 h, 2.) reflux

With hydrogenchloride; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen bromide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

sodium picrate

N^α-benzyloxycarbonyl-L-hemilanthionyl-L-isoleucyl-L-seryl-L-leucyl-L-hemilanthionine α'-methyl ester

Z-Ser-Leu-OBu^t

N-Cbz-L-Isoleucine

Refernces