Technology Process of (R)-2-<4-(4-Pentylbicyclo<2.2.2>octane-1-carbonyloxy)phenoxy>propanamide
There total 5 articles about (R)-2-<4-(4-Pentylbicyclo<2.2.2>octane-1-carbonyloxy)phenoxy>propanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82 percent / 20percent aq. K2CO3 / methanol; H2O; dimethylformamide / 1.) pH 7.00, 2.) room temp., 48 h
2: 65 percent / DCC / 4-(N-pyrrolidino)pyridine / CH2Cl2 / 18 h / Ambient temperature
3: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 18 h / Ambient temperature
4: (COCl)2, DMF / benzene / Ambient temperature
5: 35percent aq. NH3 / bis-(2-methoxy-ethyl) ether / Ambient temperature
With
ammonium hydroxide; oxalyl dichloride; hydrogen; potassium carbonate; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide;
palladium on activated charcoal; 4-pyrrolidin-1-ylpyridine;
In
methanol; dichloromethane; diethylene glycol dimethyl ether; water; ethyl acetate; N,N-dimethyl-formamide; benzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 65 percent / DCC / 4-(N-pyrrolidino)pyridine / CH2Cl2 / 18 h / Ambient temperature
2: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 18 h / Ambient temperature
3: (COCl)2, DMF / benzene / Ambient temperature
4: 35percent aq. NH3 / bis-(2-methoxy-ethyl) ether / Ambient temperature
With
ammonium hydroxide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide;
palladium on activated charcoal; 4-pyrrolidin-1-ylpyridine;
In
dichloromethane; diethylene glycol dimethyl ether; ethyl acetate; benzene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / H2 / 5percent Pd/C / ethyl acetate / 18 h / Ambient temperature
2: (COCl)2, DMF / benzene / Ambient temperature
3: 35percent aq. NH3 / bis-(2-methoxy-ethyl) ether / Ambient temperature
With
ammonium hydroxide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide;
palladium on activated charcoal;
In
diethylene glycol dimethyl ether; ethyl acetate; benzene;