15α-fluoro-8-lanost-8-en-3β-yl benzoate

Base Information

• Chemical Name: 15α-fluoro-8-lanost-8-en-3β-yl benzoate
• CAS No.: 309958-33-6
• Molecular Formula: C₃₇H₅₅FO₂
• Molecular Weight: 550.841
• Mol file: 309958-33-6.mol

Synonyms:

Chemical Property of 15α-fluoro-8-lanost-8-en-3β-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 15α-fluoro-8-lanost-8-en-3β-yl benzoate

There total 16 articles about 15α-fluoro-8-lanost-8-en-3β-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3β,20R)-4,4-dimethylcholesta-5,7-dien-3-ol (53296-71-2) → 15α-fluoro-8-lanost-8-en-3β-yl benzoate (309958-33-6)

Guidance literature:

Multi-step reaction with 11 steps

1.1: H₂ / 10 percent Pd/C / ethyl acetate

2.1: pyridine

3.1: 70 percent / HCl gas / CH₂Cl₂ / 0.5 h / -20 °C

4.1: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

5.1: BF₃-etherate / benzene / 0.5 h / 25 °C

6.1: m-chloroperbenzoic acid / diethyl ether / 0.17 h

6.2: 40 percent / BF₃-etherate / benzene / 0.25 h / 5 °C

7.1: 42 percent / conc. aq. HCl / ethanol; CH₂Cl₂ / 8 h / 70 °C

8.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 0.25 h

8.2: 79 percent / tetrahydrofuran; 2-methyl-propan-2-ol / 1.2 h / 20 °C

9.1: 47 percent / NaBH₄ / tetrahydrofuran; methanol / 20 °C

10.1: 36 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.5 h / -10 °C

11.1: HCl gas / CH₂Cl₂ / 2 h / -78 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; benzene;

Reference yield:

32-nor-lanosta-5,7-dien-3-one (7638-67-7) → 15α-fluoro-8-lanost-8-en-3β-yl benzoate (309958-33-6)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 63 percent / LiAlH₄ / tetrahydrofuran / 1.5 h

2.1: H₂ / 10 percent Pd/C / ethyl acetate

3.1: pyridine

4.1: 70 percent / HCl gas / CH₂Cl₂ / 0.5 h / -20 °C

5.1: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

6.1: BF₃-etherate / benzene / 0.5 h / 25 °C

7.1: m-chloroperbenzoic acid / diethyl ether / 0.17 h

7.2: 40 percent / BF₃-etherate / benzene / 0.25 h / 5 °C

8.1: 42 percent / conc. aq. HCl / ethanol; CH₂Cl₂ / 8 h / 70 °C

9.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 0.25 h

9.2: 79 percent / tetrahydrofuran; 2-methyl-propan-2-ol / 1.2 h / 20 °C

10.1: 47 percent / NaBH₄ / tetrahydrofuran; methanol / 20 °C

11.1: 36 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.5 h / -10 °C

12.1: HCl gas / CH₂Cl₂ / 2 h / -78 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; benzene;

Reference yield:

cholesta-4,7-dien-3-one (16826-35-0) → 15α-fluoro-8-lanost-8-en-3β-yl benzoate (309958-33-6)

Guidance literature:

Multi-step reaction with 13 steps

1.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol

1.2: tetrahydrofuran; 2-methyl-propan-2-ol / 1.17 h

2.1: 63 percent / LiAlH₄ / tetrahydrofuran / 1.5 h

3.1: H₂ / 10 percent Pd/C / ethyl acetate

4.1: pyridine

5.1: 70 percent / HCl gas / CH₂Cl₂ / 0.5 h / -20 °C

6.1: 64 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 0 °C

7.1: BF₃-etherate / benzene / 0.5 h / 25 °C

8.1: m-chloroperbenzoic acid / diethyl ether / 0.17 h

8.2: 40 percent / BF₃-etherate / benzene / 0.25 h / 5 °C

9.1: 42 percent / conc. aq. HCl / ethanol; CH₂Cl₂ / 8 h / 70 °C

10.1: potassium tert-butoxide / tetrahydrofuran; 2-methyl-propan-2-ol / 0.25 h

10.2: 79 percent / tetrahydrofuran; 2-methyl-propan-2-ol / 1.2 h / 20 °C

11.1: 47 percent / NaBH₄ / tetrahydrofuran; methanol / 20 °C

12.1: 36 percent / diethylaminosulfur trifluoride / CH₂Cl₂ / 0.5 h / -10 °C

13.1: HCl gas / CH₂Cl₂ / 2 h / -78 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; 3-chloro-benzenecarboperoxoic acid; 10% palladium on active carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; tert-butyl alcohol; benzene;

upstream raw materials:

15α-fluorolanost-7-en-3β-yl benzoate

(3β,20R)-4,4-dimethylcholesta-5,7-dien-3-ol

32-nor-lanosta-5,7-dien-3-one

32-nor-lanost-8(14)-en-3β-ol