tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Base Information

• Chemical Name: tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate
• CAS No.: 1446148-25-9
• Molecular Formula: C₂₉H₄₀N₂O₆
• Molecular Weight: 512.646
• Mol file: 1446148-25-9.mol

Synonyms:

Chemical Property of tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate

There total 2 articles about tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H41N3O6 (1453177-00-8) → tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate (1446148-25-9)

Guidance literature:

With sodium hydrogensulfite; acetic acid; sodium nitrite; In ethanol; water; at 25 ℃; for 20h;

DOI:10.1021/ja400034k

Reference yield:

C29H39N3O8 (1314311-54-0) → tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate (1446148-25-9)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 35 °C

2: acetic acid; sodium nitrite; sodium hydrogensulfite / ethanol; water / 20 h / 25 °C

With palladium 10% on activated carbon; hydrogen; sodium hydrogensulfite; acetic acid; sodium nitrite; In ethanol; water;

DOI:10.1021/ja400034k

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) + tert-butyl-(((2R,3S)-5-((R)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-methyl-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)(methyl)carbamate (1446148-25-9) → C31H46N2O6Si

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/ja400034k

upstream raw materials:

C₂₉H₃₉N₃O₈

C₂₉H₄₁N₃O₆

Downstream raw materials:

C₂₂H₂₇ClN₂O₅S