((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

Base Information

• Chemical Name: ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester
• CAS No.: 181138-33-0
• Molecular Formula: C₂₂H₃₂FNO₆Si
• Molecular Weight: 453.583

Synonyms:

Chemical Property of ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

There total 4 articles about ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.13,7]dec-6-yl ester (181138-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 2,6-lutidine / dimethylformamide / 1 h / Ambient temperature

2: 245 mg / Et₃N, DMAP / CH₂Cl₂ / 48 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19960790424

Reference yield:

(1α,2α,3α,4β,5α,6β)-6-fluoro-1,2,3,4,5-cyclohexanepentol (85716-59-2,114716-79-9,114716-82-4,114716-83-5,116049-87-7,120444-24-8,120444-25-9,130697-82-4,131435-07-9,135212-48-5,136315-50-9) → ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.13,7]dec-6-yl ester (181138-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 50 percent / TsOH*H₂O / dimethylsulfoxide / 5 h / 100 °C

2: 81 percent / 2,6-lutidine / dimethylformamide / 1 h / Ambient temperature

3: 245 mg / Et₃N, DMAP / CH₂Cl₂ / 48 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; toluene-4-sulfonic acid; triethylamine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19960790424

Reference yield:

(1R,3S,5S,6R,7R,8R,9R)-9-Fluoro-2,4,10-trioxa-tricyclo[3.3.1.13,7]decane-6,8-diol → ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.13,7]dec-6-yl ester (181138-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 2,6-lutidine / dimethylformamide / 1 h / Ambient temperature

2: 245 mg / Et₃N, DMAP / CH₂Cl₂ / 48 h / Ambient temperature

With 2,6-dimethylpyridine; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19960790424

upstream raw materials:

(1R)-1-phenylethyl isocyanate

t-butyldimethylsiyl triflate

(1α,2α,3α,4β,5α,6β)-6-fluoro-1,2,3,4,5-cyclohexanepentol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 181138-33-0 ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send