Helioxanthin derivative 5-4-2

Base Information

• Chemical Name: Helioxanthin derivative 5-4-2
• CAS No.: 203935-39-1
• Molecular Formula: C₂₀H₁₃NO₅
• Molecular Weight: 347.327
• Mol file: 203935-39-1.mol

Synonyms:

Chemical Property of Helioxanthin derivative 5-4-2

Chemical Property:

• Melting Point: 252-254 °C
• Boiling Point: 671.3±55.0 °C(Predicted)
• PKA: 13.14±0.20(Predicted)
• Density: 1.491±0.06 g/cm3(Predicted)
• Solubility.: Soluble in DMSO

Purity/Quality:

97% ^*data from raw suppliers

Helioxanthinderivative5-4-2 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Helioxanthin derivative 5-4-2

There total 13 articles about Helioxanthin derivative 5-4-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

4-(1,3-benzodioxol-5-ylmethylene)-3-[(4-iodo-1,3-benzodioxol-5-yl)methylene]pyrrolidin-2-one (911129-00-5) → 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-[1,3]benzodioxolo[4,5-f]isoindol-7-one (203935-39-1)

Guidance literature:

With palladium diacetate; potassium acetate; In 1-methyl-pyrrolidin-2-one; at 20 - 110 ℃; for 1.66667h;

DOI:10.1016/j.tet.2006.06.090

Reference yield: 32.0%

10-benzo[1,3]dioxol-5-yl-1,3-dioxa-8-aza-dicyclopenta[a,g]naphthalene-7,9-dione (203935-54-0) → 10-benzo[1,3]dioxol-5-yl-7,8-dihydro-1,3-dioxa-8-aza-dicyclopenta[a,g]naphthalen-9-one + 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-[1,3]benzodioxolo[4,5-f]isoindol-7-one (203935-39-1)

Guidance literature:

With acetic acid; zinc; at 100 ℃; for 48h;

DOI:10.1021/jm034265a

Reference yield:

(E)-4-Benzo[1,3]dioxol-5-yl-3-hydroxymethyl-2-[1-(4-iodo-benzo[1,3]dioxol-5-yl)-meth-(E)-ylidene]-but-3-enoic acid ethyl ester → 10-(1,3-benzodioxol-5-yl)-8,9-dihydro-7H-[1,3]benzodioxolo[4,5-f]isoindol-7-one (203935-39-1)

Guidance literature:

Multi-step reaction with 3 steps

1: PBr₃ / toluene / 1 h / 20 °C

2: 405 mg / aq, NH₃ / tetrahydrofuran; methanol / 11 h / 20 °C

3: 48 percent / Pd(OAc)2; AcOK / 1-methyl-pyrrolidin-2-one / 1.67 h / 20 - 110 °C

With palladium diacetate; ammonium hydroxide; potassium acetate; phosphorus tribromide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; toluene;

DOI:10.1016/j.tet.2006.06.090

upstream raw materials:

10-benzo[1,3]dioxol-5-yl-1,3-dioxa-8-aza-dicyclopenta[a,g]naphthalene-7,9-dione

4-(1,3-benzodioxol-5-ylmethylene)-3-[(4-iodo-1,3-benzodioxol-5-yl)methylene]pyrrolidin-2-one

piperonal

4-iodo-1,3-benzodioxole-5-carboxaldehyde

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