N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide

Base Information

• Chemical Name: N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide
• CAS No.: 74997-40-3
• Molecular Formula: C₂₉H₃₆FNO₄
• Molecular Weight: 481.608
• Mol file: 74997-40-3.mol

Synonyms:

Chemical Property of N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide

There total 2 articles about N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid (37927-01-8) → N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide (74997-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran / 4 °C

2: CH₂Cl₂ / 4 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0039-128X(80)90039-2

Reference yield:

phenethylamine (64-04-0) + (8S,9R,10S,11S,13S,14S,16R,17R)-9-Fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid benzotriazol-1-yl ester → N-phenylethyl 9α-fluoro-16α-methyl-11β,17α-dihydroxy-3-oxo-1,4-androstadiene-17β-carboxamide (74997-40-3)

Guidance literature:

In dichloromethane; at 4 ℃;

DOI:10.1016/0039-128X(80)90039-2

upstream raw materials:

phenethylamine

(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid