2-(4-methylcyclohexyl)cyclopentane-1-carboxylate

Base Information

• Chemical Name: 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate
• CAS No.: 117421-42-8
• Molecular Formula: C₁₆H₂₈O₂
• Molecular Weight: 252.397
• Mol file: 117421-42-8.mol

Synonyms:

Chemical Property of 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate

There total 12 articles about 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 5-methyl-p-tolylcyclopent-1-ene-1-carboxylate (100847-92-5) → 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate (117421-42-8,117468-58-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; for 3h; under 760 Torr; Ambient temperature;

Reference yield: 71.0%

ethyl 5-methyl-p-tolylcyclopent-1-ene-1-carboxylate (100847-92-5) → 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate (117421-42-8,117468-58-3) + Ethyl 2-methyl-2-(4-methylphenyl)cyclopentane carboxylate (100847-93-6,100847-94-7)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 18h; under 2280 Torr; Ambient temperature;

Reference yield:

1-cyclohex-1-enyl-4-methylbenzene (1821-23-4) → 2-(4-methylcyclohexyl)cyclopentane-1-carboxylate (117421-42-8,117468-58-3)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -78 deg C, 10 min, 2.) -78 deg C to room t.

2: Jones reagent / acetone / 0.5 h / 0 °C

3: 87.2 percent / 95 percent H₂SO₄ / 5 h / Heating

4: 75 percent / diethyl ether; toluene / 0.5 h / -78 °C

5: 81.5 percent / ZnI₂ / 1,2-dichloro-ethane / 0.17 h / Ambient temperature

6: 1.) BuLi(hexane), (i-Pr)2NH / 1.) THF, -78 deg C, 1 h 2.) THF, -78 deg C, 1 h, to room t.

7: 100 percent / p-MeC₆H₄SO₂N₃, Et₃N / CH₂Cl₂ / 4 h / Ambient temperature

8: multistep reaction; reactions under var. conditions

9: 100 percent / H₂ / PtO₂ / acetic acid / 3 h / 760 Torr / Ambient temperature

With n-butyllithium; 4-toluenesulfonyl azide; jones reagent; dimethylsulfide; hydrogen; ozone; triethylamine; diisopropylamine; platinum(IV) oxide; sulfuric acid; zinc(II) iodide; In diethyl ether; dichloromethane; acetic acid; 1,2-dichloro-ethane; acetone; toluene;

upstream raw materials:

ethyl 5-methyl-p-tolylcyclopent-1-ene-1-carboxylate

1-cyclohex-1-enyl-4-methylbenzene

1-(p-methylphenyl)cyclohexanol

para-bromotoluene