1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester

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Chemical Name:1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester
CAS No.:280117-57-9
Molecular Formula:C₂₈H₂₂N₆O₅
Molecular Weight:522.52
Hs Code.:

1-(3-amino-benzo[<i>d</i>]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1<i>H</i>-pyrazolo[4,3-<i>d</i>]pyrimidine-3-carboxylic acid ethyl ester

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Chemical Property of 1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester

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Technology Process of 1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester

There total 11 articles about 1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 280117-57-9
1-(3-amino-benzo[d]isoxazol-5-yl)-6-(2'-hydroxymethyl-biphenyl-4-yl)-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: 95 percent / H₂ / Pd/C / ethanol / 760 Torr

2.1: NaNO₂; aq. HCl / 0 °C

2.2: 55 percent / aq. NaOAc / methanol / 0 °C

3.1: K₂CO₃ / dimethylformamide / 90 °C

4.1: NaNO₂; TFA / 0 °C

4.2: 80 percent / NaN₃

5.1: 90 percent / aq. LiOH / tetrahydrofuran

6.1: (COCl)2 / CH₂Cl₂

7.1: DMAP / CH₂Cl₂

8.1: SnCl₂*H₂O / methanol / 65 °C

9.1: Heating

10.1: acetohydroxamic acid; K₂CO₃ / dimethylformamide

11.1: K₂CO₃ / ethanol / 65 °C

With hydrogenchloride; dmap; lithium hydroxide; oxalyl dichloride; acetylhydroxamic acid; hydrogen; potassium carbonate; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.07.002