(S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 151132-68-2
• Molecular Formula: C₃₄H₄₂N₂O₆Si
• Molecular Weight: 602.803
• Mol file: 151132-68-2.mol

Synonyms:

Chemical Property of (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester

There total 1 articles about (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Trimethylsilyl)ethanol (2916-68-9) + Nα-carbobenzyloxy-Nε-9-fluorenylmethoxycarbonyl-L-lysine (105751-18-6,1864003-01-9) → (S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester (151132-68-2)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; Ambient temperature;

DOI:10.1016/0040-4039(93)88067-S

Reference yield:

(S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester (151132-68-2) → (S)-2-Benzyloxycarbonylamino-6-(bis-tert-butoxycarbonylmethyl-amino)-hexanoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: piperidine / 1 h / Ambient temperature

2: NaI, NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

3: n-Bu₄NF / H₂O

With piperidine; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; sodium iodide; In water; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(93)88067-S

Reference yield:

(S)-2-Benzyloxycarbonylamino-6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 2-trimethylsilanyl-ethyl ester (151132-68-2) → (S)-2-Benzyloxycarbonylamino-6-(bis-tert-butoxycarbonylmethyl-amino)-hexanoic acid 2-trimethylsilanyl-ethyl ester (151132-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / 1 h / Ambient temperature

2: NaI, NaHCO₃ / dimethylformamide / 24 h / Ambient temperature

With piperidine; sodium hydrogencarbonate; sodium iodide; In N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(93)88067-S

upstream raw materials:

2-(Trimethylsilyl)ethanol

N_α-carbobenzyloxy-N_ε-9-fluorenylmethoxycarbonyl-L-lysine

Downstream raw materials:

2-(trimethylsilyl)ethyl N²-[(benzyloxy)carbonyl]-L-lysinate

(S)-2-Benzyloxycarbonylamino-6-(bis-tert-butoxycarbonylmethyl-amino)-hexanoic acid 2-trimethylsilanyl-ethyl ester

Refernces