(S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

Base Information

Chemical Name:(S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine
CAS No.:155133-28-1
Molecular Formula:C₁₉H₂₅NO₄S
Molecular Weight:363.478
Hs Code.:

(S)-S-<<(1S,5S,6R)-6-Hydroxyspiro<bicyclo<3.2.2>non-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

Chemical Property:

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Technology Process of (S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

There total 6 articles about (S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33993-53-2
N,S-dimethyl-S-phenylsulfoximine

: (+/-)-Spironon-8-ene-2,2'-<1,3>dioxolan>-6-one

: 155237-42-6
(S)-S-<<(1R,5R,6S)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

: 155133-28-1
(S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; Yield given. Yields of byproduct given; 1.) 30 min, 2.) 5 h;
DOI:10.1021/jo00083a034

Reference yield:

: 539-80-0
Tropone

: 155133-28-1
(S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / 145 °C

2: 28 percent / Dibal-H, CH₃Cu / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1.5 h / -50 °C

3: 89 percent / 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / -30 °C

4: 97 percent / p-TsOH / benzene / 5.5 h / Heating

5: 32 percent / LDA, oxodiperoxymolybdenum-(pyridine)(hexamethylphosphoramide) / tetrahydrofuran; hexane / 4 h

6: n-BuLi / tetrahydrofuran; hexane / -78 °C / 1.) 30 min, 2.) 5 h

With n-butyllithium; MoO₅*pyridine*HMPA; methylcopper; diisobutylaluminium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; benzene;
DOI:10.1021/jo00083a034

Reference yield:

: 86900-37-0
9-(phenylthio)bicyclo<3.2.2>nona-3,6-dien-2-one

: 155133-28-1
(S)-S-<<(1S,5S,6R)-6-Hydroxyspironon-8-ene-2,2'-<1,3>dithiolan>-6-yl>methyl>-N-methyl-S-phenylsulfoximine

Guidance literature:: Multi-step reaction with 5 steps

1: 28 percent / Dibal-H, CH₃Cu / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1.5 h / -50 °C

2: 89 percent / 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / -30 °C

3: 97 percent / p-TsOH / benzene / 5.5 h / Heating

4: 32 percent / LDA, oxodiperoxymolybdenum-(pyridine)(hexamethylphosphoramide) / tetrahydrofuran; hexane / 4 h

5: n-BuLi / tetrahydrofuran; hexane / -78 °C / 1.) 30 min, 2.) 5 h

With n-butyllithium; MoO₅*pyridine*HMPA; methylcopper; diisobutylaluminium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; benzene;
DOI:10.1021/jo00083a034