2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

Base Information

Chemical Name:2-(3-bromomethyl-phenyl)-5-nitro-1H-indole
CAS No.:1259302-03-8
Molecular Formula:C₁₅H₁₁BrN₂O₂
Molecular Weight:331.169
Hs Code.:

Synonyms:

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Chemical Property of 2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

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Technology Process of 2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

There total 5 articles about 2-(3-bromomethyl-phenyl)-5-nitro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1059628-84-0
C₁₅H₁₂N₂O₃

: 1259302-03-8
2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

Guidance literature:: C₁₅H₁₂N₂O₃; With carbon tetrabromide; In tetrahydrofuran; diethyl ether; Inert atmosphere;

With triphenylphosphine; In tetrahydrofuran; diethyl ether; at 20 ℃; for 1h;
DOI:10.1080/00397910903457415

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1259302-03-8
2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 48 h / Reflux

2.1: [Rh(coe)2Cl]2; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine / 1,4-dioxane / 72 h / Inert atmosphere; Reflux

3.1: sodium nitrate; sulfuric acid / 2 h / -20 °C

4.1: lithium borohydride / tetrahydrofuran / 24 h

4.2: Saturated solution

5.1: carbon tetrabromide / tetrahydrofuran; diethyl ether / Inert atmosphere

5.2: 1 h / 20 °C

With sodium nitrate; lithium borohydride; carbon tetrabromide; [Rh(coe)2Cl]2; sulfuric acid; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1080/00397910903457415

Reference yield:

: 618-91-7
methyl 3-iodo-benzoate

: 1259302-03-8
2-(3-bromomethyl-phenyl)-5-nitro-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: [Rh(coe)2Cl]2; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine / 1,4-dioxane / 72 h / Inert atmosphere; Reflux

2.1: sodium nitrate; sulfuric acid / 2 h / -20 °C

3.1: lithium borohydride / tetrahydrofuran / 24 h

3.2: Saturated solution

4.1: carbon tetrabromide / tetrahydrofuran; diethyl ether / Inert atmosphere

4.2: 1 h / 20 °C

With sodium nitrate; lithium borohydride; carbon tetrabromide; [Rh(coe)2Cl]2; sulfuric acid; cesium pivalate; tris(para-trifluoromethyl)phenyl phosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1080/00397910903457415