Technology Process of 3β,11,14-triacetoxy-12-benzoyloxyabieta-8,11,13-trien-6,7-dione
There total 16 articles about 3β,11,14-triacetoxy-12-benzoyloxyabieta-8,11,13-trien-6,7-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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(4bS,7S,8aR)-3,7-Dihydroxy-2-isopropyl-4b,8,8-trimethyl-4b,6,7,8,8a,10-hexahydro-5H-phenanthren-9-one
- Guidance literature:
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Multi-step reaction with 11 steps
1: pyridine / 1.5 h / 80 - 82 °C
2: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
3: 10.6 percent / pyridine / 4 h / 18 - 19 °C
4: 74.3 percent / pyridine / 4 h / 17 - 19 °C
5: 92.7 percent / sodium hydrogencarbonate, water / methanol / 0.25 h / Heating
6: 52.9 percent / CHCl3 / 80 h / Ambient temperature
7: 74.4 percent / m-chloroperbenzoic acid / CH2Cl2 / 36 h / Ambient temperature
8: 585 mg / Jones reagent / acetone / 0.04 h / 0 - 5 °C
9: zinc, 10percent HCl / benzene / 0.33 h / Heating
10: pyridine / 2.5 h / 85 - 90 °C
11: 190 mg / Jones reagent / acetone / 14 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; jones reagent; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1246/bcsj.55.1168
- Guidance literature:
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Multi-step reaction with 9 steps
1: 10.6 percent / pyridine / 4 h / 18 - 19 °C
2: 74.3 percent / pyridine / 4 h / 17 - 19 °C
3: 92.7 percent / sodium hydrogencarbonate, water / methanol / 0.25 h / Heating
4: 52.9 percent / CHCl3 / 80 h / Ambient temperature
5: 74.4 percent / m-chloroperbenzoic acid / CH2Cl2 / 36 h / Ambient temperature
6: 585 mg / Jones reagent / acetone / 0.04 h / 0 - 5 °C
7: zinc, 10percent HCl / benzene / 0.33 h / Heating
8: pyridine / 2.5 h / 85 - 90 °C
9: 190 mg / Jones reagent / acetone / 14 h / Ambient temperature
With
pyridine; hydrogenchloride; jones reagent; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; zinc;
In
methanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1246/bcsj.55.1168
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Acetic acid (1aR,1bR,3S,5aS,9bS)-7-acetoxy-8-isopropyl-2,2,5a-trimethyl-1a,1b,2,3,4,5,5a,9b-octahydro-1-oxa-cyclopropa[l]phenanthren-3-yl ester
- Guidance literature:
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Multi-step reaction with 12 steps
1: 10percent HCl / methanol / 1 h / Heating
2: pyridine / 1.5 h / 80 - 82 °C
3: lithium aluminium hydride / tetrahydrofuran / 4 h / Heating
4: 10.6 percent / pyridine / 4 h / 18 - 19 °C
5: 74.3 percent / pyridine / 4 h / 17 - 19 °C
6: 92.7 percent / sodium hydrogencarbonate, water / methanol / 0.25 h / Heating
7: 52.9 percent / CHCl3 / 80 h / Ambient temperature
8: 74.4 percent / m-chloroperbenzoic acid / CH2Cl2 / 36 h / Ambient temperature
9: 585 mg / Jones reagent / acetone / 0.04 h / 0 - 5 °C
10: zinc, 10percent HCl / benzene / 0.33 h / Heating
11: pyridine / 2.5 h / 85 - 90 °C
12: 190 mg / Jones reagent / acetone / 14 h / Ambient temperature
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; jones reagent; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; acetone; benzene;
DOI:10.1246/bcsj.55.1168
