2,2-Bis Nalbuphine

Base Information

• Chemical Name: 2,2-Bis Nalbuphine
• CAS No.: 214542-42-4
• Molecular Formula: C₄₂H₅₂N₂O₈
• Molecular Weight: 712.883
• Mol file: 214542-42-4.mol

Synonyms:

Chemical Property of 2,2-Bis Nalbuphine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,2-Bis Nalbuphine is a dimer of Nalbuphine (N232500) is a mixed opioid agonist-antagonist. Nalbuphine is an analgesic (narcotic).

Technology Process of 2,2-Bis Nalbuphine

There total 4 articles about 2,2-Bis Nalbuphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.8%

nalbuphine (20594-83-6) → 2,2'-bisnalbuphine (214542-42-4)

Guidance literature:

With phosphoric acid; oxygen; for 2160h; Irradiation;

DOI:10.1021/acs.oprd.0c00321

Reference yield:

noroxymorphone (33522-95-1) → 2,2'-bisnalbuphine (214542-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 20 °C / Inert atmosphere; Reflux; Large scale

2.1: acetic acid; tetramethylammonium triacetoxyborohydride / dimethyl sulfoxide / 1 h / 20 °C / Large scale

2.2: 60 °C / Large scale

3.1: phosphoric acid; oxygen / 2160 h / Irradiation

With hydrogenchloride; phosphoric acid; oxygen; acetic acid; tetramethylammonium triacetoxyborohydride; In tetrahydrofuran; water; dimethyl sulfoxide;

DOI:10.1021/acs.oprd.0c00321

Reference yield:

(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride (52446-24-9) → 2,2'-bisnalbuphine (214542-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; tetramethylammonium triacetoxyborohydride / dimethyl sulfoxide / 1 h / 20 °C / Large scale

1.2: 60 °C / Large scale

2.1: phosphoric acid; oxygen / 2160 h / Irradiation

With phosphoric acid; oxygen; acetic acid; tetramethylammonium triacetoxyborohydride; In dimethyl sulfoxide;

DOI:10.1021/acs.oprd.0c00321

upstream raw materials:

noroxymorphone

(-)-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride

(4R,4aS,7aR,12bS)-3-(cyclobutylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7(7aH)-one

nalbuphine

Refernces