(4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester

Base Information

• Chemical Name: (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester
• CAS No.: 374536-37-5
• Molecular Formula: C₃₇H₄₇NO₇Si
• Molecular Weight: 645.868
• Mol file: 374536-37-5.mol

Synonyms:

Chemical Property of (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester

There total 8 articles about (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid (158722-22-6) + 8-epi-15-O-t-butyldimethylsilyl-lactarorufin B (374536-32-0) → (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester (374536-37-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

lactarorufin B (52483-05-3) → (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester (374536-37-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / DMAP / dimethylformamide; CH₂Cl₂ / 5 h / 20 °C

2: 89 percent / PDC; molecular sieves 4 Angstroem / CH₂Cl₂ / 2.5 h / 20 °C

3: 92 percent / NaBH₄ / ethanol

4: DMAP; DCC / CH₂Cl₂ / 20 °C

With dmap; sodium tetrahydroborate; dipyridinium dichromate; 4 A molecular sieve; dicyclohexyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

(2R,3S)-2-hydroxy-3-amino-3-phenylpropionic acid (136561-53-0) → (4S,5R)-2,4-diphenyl-4,5-dihydro-oxazol-5-carboxylic acid (15-O-t-butyl-dimethylsilyl-lactarorufin B)-8-epi-8-yl ester (374536-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 percent / toluene / 8 h / Heating

2: 86 percent / NaOH / methanol; H₂O / 20 °C

3: DMAP; DCC / CH₂Cl₂ / 20 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane; water; toluene;

upstream raw materials:

(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

8-epi-15-O-t-butyldimethylsilyl-lactarorufin B

lactarorufin B

(2R,3S)-2-hydroxy-3-amino-3-phenylpropionic acid