benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

Base Information

Chemical Name:benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate
CAS No.:1290056-76-6
Molecular Formula:C₃₄H₄₁BN₂O₅
Molecular Weight:568.521
Hs Code.:

Synonyms:

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Chemical Property of benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

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Technology Process of benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

There total 9 articles about benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1290056-76-6
benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 20 - 80 °C / Inert atmosphere

2.1: water; lithium hydroxide / methanol / 20 °C

3.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

3.2: 20 °C

With water; potassium acetate; benzotriazol-1-ol; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1290056-76-6
benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 15 h / 80 °C / Cooling with ice

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 20 - 80 °C / Inert atmosphere

3.1: water; lithium hydroxide / methanol / 20 °C

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 20 °C

With thionyl chloride; water; potassium acetate; benzotriazol-1-ol; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 370864-42-9
4-(3-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1290056-76-6
benzyl 3-(1-(2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetyl)piperidin-4-yl)benzylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium(II) hydroxide / ethanol / 2 h / 20 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / water; tetrahydrofuran / 2 h / 0 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

4.1: benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 20 °C

With hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; trifluoroacetic acid; palladium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;