Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester
• CAS No.: 252212-14-9
• Molecular Formula: C₃₀H₃₄NO₇P
• Molecular Weight: 551.576
• Mol file: 252212-14-9.mol

Synonyms:

Chemical Property of Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

There total 3 articles about Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-Cyanoethoxy)-(ethoxy)-(N,N-diisopropylamino)phosphine (140210-65-7) → Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (252212-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / dimethylformamide; acetonitrile / 20 °C

2: I₂; H₂O

With 1H-tetrazole; water; iodine; In N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: Oxidation;

DOI:10.1039/a902330e

Reference yield:

(2R,3S)-2-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol (151265-78-0) → Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (252212-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrazole / dimethylformamide; acetonitrile / 20 °C

2: I₂; H₂O

With 1H-tetrazole; water; iodine; In N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: Oxidation;

DOI:10.1039/a902330e

Reference yield:

Phosphorous acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester → Phosphoric acid 2-cyano-ethyl ester ethyl ester (2R,3S)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-yl ester (252212-14-9)

Guidance literature:

With water; iodine;

DOI:10.1039/a902330e

upstream raw materials:

(2-Cyanoethoxy)-(ethoxy)-(N,N-diisopropylamino)phosphine

(2R,3S)-2-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-3-ol